donidalorsen
China [CN] Donidalorsen, also designated ISIS-721744 free acid and IONIS-PKK-LRX free acid, has the CAS registry number 2304692-48-4, with its structural Mol File and chemical structure diagram available for oligonucleotide analytical research. It is a synthetic antisense oligonucleotide research compound developed to suppress the production of prekallikrein (PKK). Prekallikrein serves as a key mediator driving inflammatory cascade activation linked to acute episodes of hereditary angioedema (HAE). This reagent is widely utilized in preclinical molecular biology, gene regulation and inflammatory disorder studies targeting the kallikrein-kinin pathway, supporting in vitro and in vivo investigations of HAE pathogenesis and antisense therapeutic mechanism exploration.
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