remibrutinib

China [CN]

Remibrutinib, also known by the research code LOU-064 and S9660, carries CAS registry number 1787294-07-8 with molecular formula C₂₇H₂₇F₂N₅O₃ and molecular weight of 507.53. Its full systematic chemical name is N-[3-[6-amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide. This compound is a white to off-white solid, featuring a predicted boiling point of 634.8±55.0 °C and a predicted density of 1.332±0.06 g/cm³. It exhibits excellent solubility in DMSO at 125 mg/mL (246.29 mM), ideal for cellular and biochemical pharmacological assays. Long-term storage at -20 °C is required for stability, with its structural identifiers including InChIKey and SMILES string provided for synthetic, chromatographic and analytical reference. Functionally, Remibrutinib is a potent, highly selective Bruton’s Tyrosine Kinase (BTK) inhibitor with IC50 values of 1.3 nM against BTK, 2.5 nM for FcγR-induced IL-8 release, and 18 nM for anti-IgM/IL4-induced CD69 expression. It binds to the inactive conformation of BTK with superior kinase selectivity, serving as a core preclinical research reagent for investigating B-cell signaling and developing therapies for autoimmune diseases. This reagent is supplied as solid powder as well as pre-formulated 10 mM DMSO stock solution for in vitro mechanistic and pharmacological laboratory studies.