nerandomilast
China [CN] Nerandomilast, known by research code BI-1015550, has CAS registry number 1423719-30-5, with molecular formula C₂₀H₂₆ClN₆O₂S and molecular weight of 449.97744. Its full stereochemical systematic name is 1-[[(5R)-2-[4-(5-chloropyrimidin-2-yl)-1-piperidinyl]-6,7-dihydro-5-oxidothieno[3,2-d]pyrimidin-4-yl]amino]cyclobutanemethanol. This chiral compound appears as an off-white to pale yellow solid, supplied both as raw powder and pre-formulated 10 mM DMSO stock solution for laboratory pharmacological testing. Functionally, Nerandomilast is an orally bioavailable selective PDE4B inhibitor with an IC50 value of 7.2 nM. It demonstrates favorable safety profiles and serves as a core preclinical research reagent for investigating inflammatory pathways, allergic disorders, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), supporting in vitro and in vivo mechanism studies of respiratory and inflammatory diseases.
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