elinzanetant

China [CN]

Elinzanetant, also known as research codes NT-814 and GSK1144814A, carries CAS registry number 929046-33-3 with molecular formula C₃₃H₃₅F₇N₄O₃ and molecular weight of 668.66. Its full stereochemical systematic name is N-{6-[(7S,9aS)-7-(hydroxymethyl)-octahydropyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl}-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide. This chiral compound exists as a white to pale yellow solid, with a predicted boiling point of 672.1±55.0 °C and a predicted density of 1.40±0.1 g/cm³. It dissolves in DMSO up to 100 mg/mL (149.56 mM) with sonication required for full dissolution, and long-term storage at -20 °C is mandatory to retain stability; structural identifiers including InChIKey and SMILES string are supplied for synthetic, chromatographic and analytical lab reference. Functionally, Elinzanetant is an orally bioavailable selective neurokinin NK-1/NK-3 dual receptor antagonist. It serves as a core preclinical research reagent for investigating vasomotor regulation, neurokinin signaling pathways and schizophrenia pathogenesis, and is available as solid powder as well as pre-formulated 10 mM DMSO stock solution for in vitro pharmacological and neurobiology mechanistic assays.