Polymyxin E sulfate

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Polymyxin E sulfate
Posting date : Apr 12, 2013
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30-
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Polymyxin B sulfate colistin ] characters ] white or yellowish powder; odorless or almost odorless; with a moist. Soluble in water, slightly soluble in ethanol, insoluble in chloroform or * *, * *. 1% aqueous solution pH value should be 4.0-6.5. [ ] ( 1 ) pharmacology pharmacodynamics of narrow spectrum antibiotic. There are strong antibacterial activity against Gram-negative bacteria, sensitive bacteria enterobacter, Escherichia coli, Pseudomonas aeruginosa, Klebsiella, Salmonella, Shigella, Salmonella and Vibrio Pasteur. And Proteus spp., Brucella, Serratia and all Gram-positive bacteria are resistant to this product. Polymyxin class for slow sterilizing agent, a major role in the bacterial cell membrane, when in contact with the sensitive bacteria, free amino of the chemical structure of ( electropositive ) and the bacterial cell membrane phosphate phosphorus esters ( negative charge ) combined with, the increase in membrane permeability, resulting in heavy substances such as amino acids, purine, pyrimidine, external leakage to intracellular K+. Can also affect the nucleoplasm and ribosome function. Bacteria on the product is not easy to produce drug resistance, and no

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