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Rheumatic Arthriris Pain Relief Patch:Rheumatism is a set of infringement of joints, bones, muscles, blood vessels and related soft tissue or connective tissue disease, most of them autoimmune diseases.Much more discreet and slow, long course of disease, and most have a genetic predisposition.Diagnosis and treatment of all has the certain difficulty;How can detect different autoantibodies in the blood, may be associated with different HLA subtype;For non steroid anti-inflammatory drugs (NSAID), glucocorticoid and immunosuppressants have better short-term or long-term sexual response.
Rheumatic Arthriris
Rheumatism is a set of infringement of joints, bones, muscles, blood vessels and related soft tissue or connective tissue disease, most of them autoimmune diseases.Much more discreet and slow, long course of disease, and most have a genetic predisposition.Diagnosis and treatment of all has the certain difficulty;How can detect different autoantibodies in the blood, may be associated with different HLA subtype;For non steroid anti-inflammatory drugs (NSAID), glucocorticoid and immunosuppressants have better short-term or long-term sexual response.
Disease is introduced
Generally think that cause joint and muscle pain diseases are attributable to rheumatism.Continue down, still on the classification of rheumatism, generalized the existing more than 100 kinds of diseases, including infectious, autoimmune and metabolic, internal secretory, hereditary, degenerative, tumor, local, toxic and other causes of disease.In a narrow sense should be confined to the internal medicine category of dozens of diseases related to immune.Some of the disease or the interdisciplinary, such as gout, osseous arthritis, infectious arthritis, etc.
Classification of diseases
1. Give priority to with arthritis, such AS rheumatoid arthritis (RA), who began, the disease is divided into childhood and adult, ankylosing spondylitis (AS) and psoriatic arthritis.
2. Related to infection, such as rheumatic fever, lyme disease, syndrome, Wright reactive arthritis.
3. Diffuse connective tissue diseases: systemic lupus erythematosus (SLE), primary sjogren's syndrome (pSS), systemic sclerosis (SSc), multiple myositis (PM) and dermatomyositis (DM), mixed connective tissue disease (MCTD), vasculitis
Causes
1.Immune response: the body of exogenous or endogenous antigenic substances directly or through the stimulation of macrophages present, make the corresponding T cell activation, part of the T - caused cells to produce large amounts of a variety of inflammatory cytokines all kinds of tissues and organs different degrees of injury or damage;Part of the T - cells activated B - again, produced a large number of antibodies, direct or complex formation with antigen immune complex, make the tissue or organ damage or destruction.In addition by mononuclear cells of monocyte chemotactic protein (such as MCP - 1), can also be involved in the inflammatory response.Most of rheumatoid disease, or due to infection of exogenous antigen material, or due to generate endogenous antigenic substance in the body, can start or exacerbate this autoimmune reaction, can appear in a variety of serum antibodies.
2. Genetic background: recent studies have shown that some rheumatic diseases, connective tissue diseases, in particular, the expression of genetic susceptibility and disease, and patients is closely related to early or atypical cases and prognosis of disease has a certain meaning;The HLA (human leukocyte antigen) is most important.
3. The infection factors, according to a study to clarify the years a variety of infection factor, microbial antigens or super antigen, can be directly or indirectly stimulate or launch an immune response.
4. Endocrine factors: studies have demonstrated that estrogen and progesterone disorders, related to the occurrence of a variety of rheumatism.
5. Environment and physical factors, such as ultraviolet radiation can induce SLE.
6. Others: some drugs such as procaine amide, some oral contraceptives may induce SLE and ANCA positive small vasculitis.
Clinical manifestations of
1. Rheumatism is mostly about the disease and symptoms, and can be as high as 70-80%, about 50% is only pain, or red, swollen, heat, pain, and impaired the overall inflammation;Multiple joints involved.Abuse and joint size inspects have different diseases.
2. The heterogeneity, that is, the same disease, there are different subtypes, due to the genetic background, causes, mechanism is also different, therefore the types of clinical manifestation, symptoms, severity and response to treatment.
3. Rheumatism is violation of multi-system disease, pathological overlap, many similar symptoms, such as MCTD for the type of performance.
4. In a variety of serum antibodies and immune complex (CIC), and can be deposited on tissue (skin, synovial) or organ disease (kidney, liver).
5. Renault phenomena often appear in this kind of disease, such as SLE, MCTD.
Disease diagnosis
Disease
Because of rheumatism is varied, should collect medical history in detail, in addition to the personal history, including family history;The comprehensive physical examination, paying special attention to joint symptoms, skin and mucosal lesions, whether Renault phenomenon, vasculitis lesions.According to the preliminary examination different disease history.
Laboratory tests
(1) routine inspection: rheumatism is assault and systemic system of multiple organ disease, so to make a comprehensive examination, blood, urine, blood sedimentation, CRP, comprehensive biochemical examination (liver function, renal function, muscle enzymes, etc.).
(2) serologic test: (1) general: RF, C3, C4 and CH50, CIC, IgG, IgA, IgM, IgE.(2) the particularity: a. antinuclear antibody spectrum of rheumatoid disease, diagnosis and differential diagnosis has the very vital significance.ANA usually do first, such as the drop degree > 1:40, should further check for other projects.B. HLA: although HLA has close correlation with rheumatism, but at present, there are few know about its and commonly used, more specific such AS HLA b - 27 on AS positive rate can be AS high AS 81.8%, also to Wright syndrome can reach 40%, in psoriasis is only 10%;DR4 / DR1 on positive RA 49-79%, JRA was 7%, but the JRA Dw4 26%, Dw14 was 47%, the DR3 in SLE is only 2.7%, in pSS is 5.6%.Only 3.3% of Behcet's disease HLA B5 is positive.C. other: such as Anti keratin antibody (AKA), resistance to histones antibody (Anti - histone antibody), for antiphospholipid antibodies, antinuclear weeks factor (ANCA) of diagnostic reference value to some disease.
(3) joint fluid check: fresh joint fluid is very important, should make a rule, the raise, serology and immunology examination.
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