Loperamide HCl

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Loperamide HCl
Posting date : Nov 28, 2012
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30-
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Loperamide hydrochloride Synonyms: Lopemin; Loperamide HCl CAS: 34552-83-5 EINECS: 252-082-4 Assay: 99% min. Standard: BP/EP/USP Packing: 1kg/foil bag; 5kg/drum. Character: White Solid. Usage: used as an antidiarrheal, treatment of diarrhea. Biological Activity: High affinity μ -opioid receptor agonist with peripheral selectivity (K i values are 2, 48 and 1156 nM for μ -, δ - and κ -opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca 2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca 2+ channels and at higher concentrations it reduces Ca 2+ flux through NMDA receptor operated channels. MSN: ycgsales01@yccreate.com

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