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Medical dynamic youth polypeptide
Youth anti-aging peptides in the field of application
Xin Run the medical department of science and technology to compile
First, an overview of youth polypeptide
Youth polypeptide is secreted by the adenohypophysis relative molecular weight of 22000, from 191 amino acids composed of single-chain disabilities peptide, in which the blood half-life of 17-45 minutes. In the NP role, the in vivo synthesis of IGF-1, now widely recognized that this peptide is the role of mammals in vivo the major media. NP role in a wide range, not only acting on a specific organ system, and can induce the body to enhance the metabolic activity and reduce fat production, to prevent hypoglycemia when you are hungry to re-distribution of adipose tissue, promoting liver, cardiovascular and central nervous system of men and women of reproductive organs of various organizations, such as protein synthesis. This study shows that low-dose NP treatment of middle-aged and old men`s physical, mental psychological, vasodilation, blood lipids and other implications, also confirmed the breadth of its role, the recent study found becker, etc., NP in the induction and maintenance of the penis ED also has an important role, NP pulsatile-release of the disorder may lead to sexual dysfunction. For example, loss of libido, erectile dysfunction, etc., our study shows that, NP part of the treatment can have erectile dysfunction in elderly patients with improved erectile function, thus speculate that the lack of NP in some middle-aged and old male erectile dysfunction pathogenesis of certain role. Animals and humans in old age and aging process, the tissue`s ability to decrease protein synthesis, in normal adults after 40 years of age, muscle tissue, liver, kidney, spleen, skin and bone tissue protein synthesis to reduce weight, resulting in a variety of physiological functions decline NP secretion people is the age-related, increased during adolescence, peak in late adolescence, and then gradually declined. Over 60 years of age dropped to NP secretion puberty 1 / 6, that is, the growth of age had a relative lack of NP. A large number of experiments have proved that NP secretion in old age is to reduce protein synthesis to reduce one of the important reasons. Therefore, by increasing blood levels of NP downturn in our old age to reduce protein synthesis to improve the physiological function may be effective in improving quality of life of older persons. Rudman, such as in 1990 first reported the application of NP in elderly men to live after the good results, the subjects increased muscle and bone density increase blood fats and lower LDL. Subsequently, a number of scholars have reported the application of NP clinical study, in which the longest treatment time to achieve 10 years, the results are prompted to add NP middle-aged men can have beneficial physical changes, including lean weight, fat reduction, increased bone mineral density, cardiovascular tolerance increased, mood improvement. Lowering blood lipids, physical enhancement and energy to improve. Improve sleep. Our research results showed that: subjects in a small dose of NP3-month and six months later, the blood IGF-1 levels increased significantly, physical. Vasomotor symptoms, psychological symptoms, sexual function before treatment symptoms were significantly improved, blood total cholesterol in the treatment of six months after a significant drop; At the same time, grip strength increased, reduced abdominal circumference, and no significant changes in body weight. This prompted to add small doses of NP can indeed improve the number of middle-aged men symptoms of recession. Information abroad, NP treatment of the most common adverse reactions to body fluid retention, hand, foot, ankle edema around; partial paresthesia to finger the most obvious; carpal tunnel syndrome; systemic muscle and joint pain. Most side effects symptoms appear in the January-March after NP treatment, which a number of side effects with the drug and dose to reduce or go away. In this study, because we used smaller doses, in patients with the incidence of adverse reactions reported in the literature than less, and minor. In the 6 months follow-up observation, in patients with urinary flow rate, IPSS, blood PAS, blood sugar, prostate volume, as well as liver and kidney function, ECG before and after treatment did not change significantly on short-term low-dose NP treatment is safe. However, NP and IGF-1 can promote the role of cell division, long-term replacement therapy will induce tumor has yet to be further observation. NP replacement therapy should be cautious, to be strictly selected cases, and pay attention to the appropriate dose.
NP and anti-aging
Youth of the biological characteristics of peptides
NP by NP cells in the anterior pituitary gland secretion, which accounts for the former Leaf pituitary cells of 50%. 1955 isolated from human pituitary NP, 1979 years of NP cloned cDNA, NP gene is a multi-gene family, which includes three members of NP, CS, PRL gene is a multi-copy gene, NP-N is the main NP genes, it has 5 exons and 4 introns, its original transcription of the 1300bp product mRNA, 5 `end after a Canadian cap, 3` end to add poly A, truncated intron into a mature mRNA, NP encoding 217 amino acid precursor, translation after the cut off of 26 amino acid signal peptide, the formation of the molecular weight of 22kDa single-chain 191 amino acid peptide NP. NP in the blood half-life of 17-45 minutes, on the secretion of NP receptors throughout the body of the organization, NP The main physiological role is to promote the growth and development. Regulation of NP secretion, NP secretion for explosive secretion, the highest level of secretion of puberty, it is through the promotion of liver cells secreted IGF-1, IGF-1 and IGF-1 binding protein, on the one hand the protection of IGF-1 make it difficult to degradation, on the other hand, plays a buffer in the blood IGF-1 role, and thus by measuring IGF-1, IGF-1BP1 to reflect the level of NP in the blood. 24-hour serum NP volatile, and its secretion is characterized by the following: the normal state of NP based on a very low level l), but at a low level may be based on spontaneous, continuous NP peak, peak up to l, which become secretory pulse, pulse frequency and amplitude at different times and vary significantly between; NP secretion law there day and night, night and reached the peak secretion of human sleep after 45-90 minutes significantly increased, up to l, the other factors such as the spirit, hunger, stress and sleep and other factors may affect its secretion, resting in bed state NP level measured less than regular, minor activities that could increased after exercise or a higher, acute hypoglycemia can significantly higher NP. Regulation of NP is divided into four levels, one for the cellular level, two for the adenohypophysial level, three for the level of the hypothalamus, four for the central level. Hypothalamic secretion of GHRH to promote the secretion of pituitary NP, which is secreted endostatin inhibit pituitary secretion of NP. And IGF-1, cortisol negative feedback regulation of anterior pituitary, and pituitary hormone secretion is the promotion of NP. Its level of inhibition of fat cells produce, and promote liver, muscle, bone, cartilage, kidney and skin growth. Other factors such as exercise, stress, emotional excitement, fasting can promote NP secretion: Obesity, free fatty acid secretion while inhibiting NP. Were increased with age, NP secretion volume, there have been a downward trend (Figure 1 Figure 2). 20-31 year-old fell about 14 percent, to 60 years of age approximately half the volume of NP secretion. The age of 20 NP secretion of d, 40-year-old at the time of d, 80-year-old only d.
NP, GNF not only affect in the body, moreover can improve the psychology, therefore, NP, GNF are connect psychological and body`s bridge.
Senile target Improvement rate %
Movement, strength and fat
Muscular strength 88
Muscle size 81
Fat reduction 72
Movement endurance 81
Skin and hair
Skin texture 71
Skin thickness 68
Skin elasticity 71
Wrinkles disappear 61
Hair Regeneration 38
Healing, flexibility and resistance
Wound healing 55
Other wound healing 61
Wound healing capacity 71
low back flexibility 83
Cold resistance 73
Sexual function
The frequency of sexual intercourse 75
Duration of penile erection 62
Emission frequency 57
Orgasm 58
Menstrual cycle 39
Energy, emotion and memory
Energy level 84
Emotional Stability 67
Attitude to life 78
Memory 62
※ The average treatment time of 180 days, 15 days to see the effect of 720 days can be maintained.
Youth peptide treatment indications:
★ subhealth, Anti-Aging
★ heart disease
★ heart failure, cardiac arrest, stroke
★ diabetes
★ arteriosclerosis
★ lung function, lung disease
★ osteoporosis
★ obesity
★ sexual dysfunction
★ psychological and emotional changes
★ Parkinson`s disease
★ Alzheimer`s disease
Senescence symptoms diagnosis
Symptoms: lack of energy, lack of interest in life, reduced libido, reduced sex life.
Psychological symptoms:
Weakened sense of happiness, energy, lack of vitality, decreased ability to work.。
Emotional expression:
Emotional instability, self-control ability, anxiety and depression, social isolation increased.
Signs:
body weight, extracellular fluid volume reduction, Lower bone mineral density, body fat increased, especially abdominal fat, increased waist, serum HDL lower, LDL increased Lower body blood flow, metabolic rate, muscle weight, muscle strength weakened, reducing the daily activities, decreased oxygen reserve capacity.
Youth peptide substitution therapy to physiological and psychological function
6 months after treatment, muscle weight increased by an average of 8.8% Wearing white to improve the distribution of blood lipids: LDL lowering elevated HDL
Non-fasting treatment of 6 months, an average reduction of 14.4% fat Enhance the bone
So energetic Promote wound healing
Enhanced sexual function The promotion of hair growth
Increase the radiance of your
Reversal of aging-induced heart, liver, spleen, kidney dysfunction, etc. skin, elasticity and thickness
Increase in cardiac output and stroke volume Increase in extracellular fluid volume
Enhance immune function To improve the emotional state
Increased activity Enhance memory
Improve the renal function Improve sleep
Lower blood pressure
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