dapoxetine

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dapoxetine
Posting date : Mar 14, 2008
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30-
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Assay: 98.5% min Main use: Premature Ejaculation. Dapoxetine hydrochloride was originally an antidepressant and one of the side effects of several antidepressants is retarded ejaculation (an inability to reach orgasm), inability to sustain an erection and/or impotence. Mechanism: Dapoxetine, a new antidepressant, has been found to be safe and effective for the treatment of premature ejaculation, according to two major clinical trials. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI) with a short half-life developed specifically for the treatment of men with PE. SSRI's increase 5-HT neurotransmission however, most available SSRI's such as fluoxetine, sertraline, and paroxetine, which have been shown to increase ejaculatory latency time, do not reach peak plasma concentrations for several hours. This does not allow for the available drugs to be used as on-demand preparations. Dapoxetine has inhibitory effects on serotonin reuptake and the time to maximal plasma concentration is only 1 hour. The initial elimination half-life is 1.2 hours and the plasma concentration at 24 hours is < 5% of the maximal concentration. These properties allow for dapoxetine to be delivered as an on-demand preparation. Side effect: It is digested by the intestines and the stomach after taking; it will become effective about 20 to 30 minutes when it is taken orally; its effect will last for several ten days; and its side effect is small, which may have symptoms, such as, slightly headache and nausea, but they will disappear soon.

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