9-amino-camptothecin

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9-amino-camptothecin
Posting date : Dec 26, 2007
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CAS #: 104195-61-1 Molecular formula:C20H15N3O6 Molecular weight:393.35 Formulation: White powder Purity: 99% A process for preparing the 9-amino camptothecin of formula (I); said process comprising: (1) reacting a compound of formula (III), wherein the hydroxy group on ring A is in the 10- or 12-position, with a nitrating agent, so obtaining a corresponding compound of formula (IV); (2) converting the compound of formula (IV) into a corresponding compound of formula (V), wherein XO is a group that can be removed reductively; and (3) reductively removing the said XO group and reducing the nitro group of the compound of formula (V), so obtaining the 9-amino camptothecin of formula (I), a known antitumor compound. The present invention includes also in its scope compounds having the above reported formula (V) and compound of formula (VII), which are endowed with antitumor activity

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