NNC-711 drug for sale

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Product
NNC-711 drug for sale
Posting date : May 08, 2018
Membership
Free Member Scince May 07, 2018
Min. Order Quantity
1
Supply Abillity
Yes
Port
440
Payment Terms
visa, mastercard, American express, bank transfer, bitcoin, litecoin, dash, zcash
Package
OEM
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Category
Contact
Thomas Vendor
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Product Detail
Company Info
 
Quick Detail
Place of Origin
United States [US]
Brand Name
NNC-711
HS-CODE
30-
Package & Delivery Lead Time
Package
OEM
Detailed Description
It is assumed that the therapeutic effect of NNC-711 drug in schizophrenia and bipolar disorder of type 1 is due to the combination of partial agonistic activity against Pb-dopamine and 5HT1a-serotonin receptors and antagonistic activity against 5HT2a-serotonin receptors. NNC-711 in animal experiments showed antagonism with respect to dopaminergic hyperactivity and atomism with respect to dopaminergic hypoactivity. NNC-711 has a high in vitro affinity for LA- and D; -dopamine receptors, 5HT1a and 5HT2a-serotonin receptors and moderate affinity for D. | - dopamine, 5HT2C- and 5HT7-serotonin, ai-adrenergic receptors and Pumped and new receptors.NNC-711 is also characterized by moderate affinity for the sites of serotonin reuptake and lack of affinity for m-holinoretseptoram. Some clinical effects of NNC-711 may be due to interactions with other receptors than dopamine and serotonin receptors. When administered NNC-711 in healthy volunteers at a dose of 0.5 to 30 mg once a day for 2 weeks, a dose-dependent decrease in the binding of 11C-rakloprid, 1) 2/03-dopamine receptor ligand, with a caudate nucleus and a fence according to positron data emission tomography.After ingestion, NNC-711 is rapidly absorbed, and its maximum concentration in the blood plasma is reached after 3-5 hours. NNC-711 is minimally subjected to pre-systemic metabolism. The absolute bio-inhalation of tablets is 87%. Foods high in fat do not affect the pharmacokinetics of NNC-711. NNC-711 is intensively distributed in tissues, the apparent volume of distribution is 4.9 l / kg, indicating a significant extravascular distribution. At therapeutic concentrations in the blood, NNC-711 and its basic metabolite dehydroarcheprazole bind more than 99% to blood plasma proteins, mainly albumin.NNC-711 is metabolized in the liver in three ways: dehydrogenation, hydroxylation and N-dealkylation. According to in vitro studies, NNC-711 dehydrogenation and hydroxylproduction occur under the action of CYP3A4 and CYP2D6 isoenzymes, and N-dealkylation is catalyzed by the CYP3A4 isoenzyme. NNC-711 is the main active substance in the blood. In the equilibrium state, the area under the concentration-time curve (AUC) of NNC-711.
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