SNAP-5114 drug for sale

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Product
SNAP-5114 drug for sale
Posting date : May 08, 2018
Membership
Free Member Scince May 07, 2018
Min. Order Quantity
1
Supply Abillity
Yes
Port
470
Payment Terms
visa, mastercard, American express, bank transfer, bitcoin, litecoin, dash, zcash
Package
OEM
Keyword :
Category
Contact
Thomas Vendor
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Product Detail
Company Info
 
Quick Detail
Place of Origin
United States [US]
Brand Name
SNAP-5114
HS-CODE
30-
Package & Delivery Lead Time
Package
OEM
Detailed Description
SNAP-5114 drug is a novel legal hypnotic preparation of pyrazolo-pyrimidine type differs in chemical structure from benzodiazepines and other hypnotics. Selectively binds to benzodiazepine receptors. Significantly reduces the latent time of falling asleep, prolongs the time of sleep (in the first half of the night), does not cause changes in the ratio of different phases of sleep. When used in a dose of 5 mg and 10 mg for 2-4 weeks does not cause pharmacological tolerance. In addition, it has a sedative, slightly expressed anxiolytic, anticonvulsant and central muscle relaxant effect. Excites benzodiazepine receptors of GABA type A receptor complexes. Interaction with receptors leads to the discovery of neuronal ionoform channels for chlorine ions, the development of hyperpolarization and enhancement of inhibition processes in the central nervous system.After ingestion quickly and almost completely (about 71%) is absorbed from the gastrointestinal tract, Cmax in the blood is reached after 1 hour. As a result of presystemic metabolism, absolute bioavailability is 30%. The plasma concentration is directly proportional to the dose. Taking the drug immediately after ingestion can delay the Cmax time for 2 hours without affecting the absorption of the drug.It is a liposoluble compound. Vd after intravenous administration is 1.4 ± 0.3 l / kg. Binding to plasma proteins is about 60% (the probability of interaction with other drugs is very small). Excreted in breast milk.In the primary metabolism, aldehyde oxidase participates and leads to the formation of 5-oxozeleplon. CYP3A4 also participates in the metabolism of zaleplon with the formation of dezetyl-zaleplon, which in turn, with the help of aldehyde oxidase, is converted into 5-oxo-desethyl-zaleplon. In the future, oxidation products undergo conjugation with glucuronic acid. All metabolites are inactive. When used in doses up to 30 mg / cumulation is not observed. T1 / 2 zaleplon - about 1 hour.
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