Dapoxetine (Priligy, Westoxetin) drug for sale

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Product
Dapoxetine (Priligy, Westoxetin) drug for sale
Posting date : May 08, 2018
Membership
Free Member Scince May 07, 2018
Min. Order Quantity
1
Supply Abillity
Yes
Port
89
Payment Terms
visa, mastercard, American express, bank transfer, bitcoin, litecoin, dash, zcash
Package
OEM
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Thomas Vendor
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Product Detail
Company Info
 
Quick Detail
Place of Origin
United States [US]
Brand Name
Priligy
HS-CODE
30-
Package & Delivery Lead Time
Package
OEM
Detailed Description
An antiparkinsonian agent, an MAO inhibitor. Dapoxetine (Priligy, Westoxetin) is a selective irreversible inhibitor of MAO type B, an enzyme that determines 80% of the activity of MAO in the brain and the metabolism of dopamine. Dapoxetine is 30-80 times more active against MAO type B, compared with MAO type A. As a result of the inhibitory effect of the drug on MAO type B in the central nervous system, the level of dopamine increases, the formation of toxic free radicals, excessive formation of which is observed in Parkinson's disease. Dapoxetine also has a neuroprotective effect. Unlike non-selective MAO inhibitors, the drug does not block the metabolism of nutrient-derived biogenic amines (eg, tyramine) in therapeutic doses, and therefore does not cause a tyramine-mediated hypertensive syndrome ("cheese" effect).Dapoxetine is rapidly absorbed after ingestion, Cmax in blood plasma is reached after 0.5 h. Absolute bioavailability of the drug after a single administration is about 36%. Food does not affect the time to reach Cmax rasagiline in the blood, but when consuming fatty foods Cmax and AUC are reduced by 60% and 20%, respectively. Pharmacokinetics of the drug is linear in the dose range of 0.5-2 mg.Rasagiline is almost completely metabolized in the liver. Biotransformation is carried out by N-dealkylation and / or hydroxylation to form the main biologically inactive metabolite - 1-aminoindane, as well as two other metabolites - 3-hydroxy-N-propargyl-1-aminoindane and 3-hydroxy-1-aminoindane. The drug is metabolized with the participation of the CYP1A2 isoenzyme.
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