Protease Substrates Screening Service | Global Trade leader ecrobot

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Protease Substrates Screening Service

Posting date : Jul 11, 2017

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Free Member Scince Nov 07, 2012

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Protease Substrates

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CHEMICAL | Pharmaceut | Human bloo | Antisera &

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Bella Smith

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Place of Origin

United States [US]

Brand Name

Creative Biolabs

HS-CODE

3002-10

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Detailed Description

Phage display peptide libraries that display random 5-20 mer peptides have been widely used to determine protease substrate [sequence] specificity for a large number of enzymes and semi-purified cell extracts. This technique has been playing a critical role in designing inhibitors and activators of proteases.

In comparison with phage display peptide libraries used in other fields, phage display peptide libraries used to identify the preferred substrate sequences of a protease usually express a fusion tag at the N-terminus of the peptide sequences, while, like in regular phage display peptide libraries, the minor coat viral protein pIII is located at the C-terminus of the peptide sequences. The N-terminal fusion tag is intended to bind the phage particles to a solid support. Scientists from Creative Biolabs have designed and built up a unique tag, HiAffi-tag, which is derived from Protein G, thus has strong binding affinity to most IgG coated on a solid surface. In contrast to His Tag and Strepavidin Binding Motifs used in such libraries, HiAffi-tag enables the best capture of the phage particles to the solid support and the least steric hindrance for proteolysis of the substrate peptides. More information, please visit the website: http://www.creative-biolabs.com/Protease-Substrate-Screening.html