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29-
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Caffeic Acid Phenethyl Ester
【Component】Caffeic acid phenethyl ester
【Synonyms】beta-phenyl ethyl ester; 3,4-hydroxy-trans-cinnamic acid phenethyl ester
【Assay】 98% min
【Appearance】 Yellow to light yellow crystalline powder
【Function & Usage】 Caffeic acid phenethyl ester is one of the main active component, with anti-inflammatory and anti-tumor effect, is an important raw material and pharmaceutical intermediates. Caffeic acid phenethyl ester as an anti-swelling medication in a foreign country has entered Phase III clinical trials. Commonly used in the preparation of health care products.
1. Antioxidant is a strong antioxidant. Have anti-inflammatory, disease-resistant microorganisms such as the role of the original removal of reactive oxygen species and by inhibition of xanthine oxidase (X0), NOS activity and reduced consumption of SOD, which played the role of anti-oxidation.
2. Anti-inflammatory effect of inhibition of carrageenan-induced adjuvant arthritis, pleurisy and paw edema in rats, the other, CAPE can inhibit the production of N0, N0 is catalyzed L-arginine iNOS produces a free radical, too much NO can cause damage to the body, but also in its own immune diseases such as rheumatoid arthritis, ulcerative colitis and systemic lupus erythematosus and other increases in NO synthesis. CAPE can inhibit the LPS + IFN-γ levels induced by the increase in N0, CAPE on the cell membrane by inhibiting the release of arachidonic acid and inhibition of COX-1 and COX-2 activity, which has played a role in anti-oxidation.
3. Anti-tumor effects with anti-cancer activity, can inhibit tumor cell proliferation, on the toxic effects of certain cancer cells, CAPE on the specific destruction of tumor cells. While malignant lesions have cytotoxicity, CAPE of melanoma, colon cancer and the role of gastric cancer cell lines is very strong, showing the inhibition of cancer cell characteristics.
4. Of liver injury: liver damage, cancer, ischemia and reperfusion, such as the role of inhibitory mechanisms.
5. Colorectal sense of the role of bacteria on cultured HCT116 colon cancer cell proliferation, cell cycle and apoptosis. CAPE on HCT116 cells significantly inhibited proliferation, its mechanism and its cell cycle arrest and induction of apoptosis.
【Application】 Caffeic acid phenethyl ester industry mainly for the pharmaceutical industry.
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