Genistein

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Genistein
Posting date : Mar 17, 2011
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06-
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Original Plant:Seed of Sophora japonica L. Synonyms: CI 75610; Genestein; genisteol; genisterin; prunetol; sophoricol Chemical Name:4',5,7-trihydroxyisoflavone 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Specification: 98% Test Method: HPLC Molecular Formula: C15H10O5 Molecular Weight: 270.23 CAS No.: 529-59-9 Melting point: 297~298℃ Solubility: Soluble in DMSO and Ethanol,hardly dissolve in water. Pharmacology Action: Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities.

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