Bilberry Extract

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Bilberry Extract anthocyanins anthocyanosides Vaccinium myrtillus L Common name: bilberry or European blueberry Overview Bilberry has been used for centuries, both medicinally and as a food in jams and pies. It is related to the blueberry and is native to Northern Europe. Bilberry fruit contains chemicals known as anthocyanosides, plant pigments that have excellent antioxidant properties. They scavenge damaging particles in the body known as free radicals, helping to prevent or reverse damage to cells. Antioxidants have been shown to help prevent a number of long-term illnesses such as heart disease, cancer, and an eye disorder called macular degeneration. Bilberry also contains vitamin C, which is another antioxidant. Not many studies have been done to examine bilberry specifically. Even fewer studies have been done in humans. Most of the suggestions about bilberry's effectiveness come from research on similar antioxidants, or from test tube and limited animal studies, and is used in bellow applications: Chronic venous insufficiency Diabetes Atherosclerosis Diarrhea and wounds Vision Vaccinium myrtillus L. fruits contain the highest amounts of anthocyanins in comparison with other berries such as Vaccinium angustifolium. The amount of anthocyanins in the berries ranges from 300 to 698 mg/100 g and increases during the ripening process. Anthocyanins are water-soluble pigments responsible for red, pink, mauve, purple, blue,or violet color of most flower and fruits. These compounds act as potent antioxidants and phosphodiesterase inhibitors,thus being particularly effective in the amelioration of capillary resistance and permeability and are widely used in dietary botanicals and pharmaceutical market for the treatment of vascular and vision disorders. The bilberry anthocyanins are C-3 glucosides, galactosides, and arabinosides of cyanidin, peonidin,delphinidin, malvidin and petunidin.There is many low quality or adulterated extracts in the market worldwide, so it is very important to distinguish if you have got the right products. Anthocyanidins, are anthocyanins without the sugar moiety and should be considered as anthocyanin degradation products, occurring when there has been incorrect extract production or wrong storage. If your products are the right products, it should have: Delphinidin-3-O-galactosid, Delphinidin-3-O-glucoside, Cyanidin-3-O-galactoside, Delphinidin-3-O-arabinoside, Cyanidin-3-O-glucoside, Petunidin-3-O-galactoside, Cyanidin-3-O-arabinoside, Petunidin-3-O-glucoside, Delphinidin, Peonidin-3-O-galactoside, Petunidin-3-O-arabinoside, Peonidin-3-O-glucoside, Malvidin-3-O-glucoside, Peonidin-3-O-arabinoside, Malvidin-3-O-galactoside. Cyanidin, Malvidin-3-O-arabinoside,Petunidin, Peonidin, Malvidin. Chemical structure of anthocyanins R R1 R2 R3 Cyanidin 3-O-glycoside OH OH H arabinose or glucose or galactose Delphinidin 3-O-glycoside OH OH OH arabinose or glucose or galactose Malvidin 3-O-glycoside OCH3 OH OCH3 arabinose or glucose or galactose Peonidin 3-O-glycoside OCH3 OH H arabinose or glucose or galactose Peonidin 3-O-glycoside OH OH OCH3 arabinose or glucose or galactose Bilberry Extract anthocyanins HPLC Fingerprint Why Organic Herb Inc. Bilberry Extract: A.) Organic Herb Inc. Bilberry Extract is 100% extracted from natural and European original bilberry fruit, very safe and more bioactive. B.) Organic Herb Inc. Bilberry Extract almost have all the anthocyanins peaks and the content ranges from 36% to 38%. C.) Organic Herb Inc. offer Bilberry Extract at a very lower price with a very high and uniform quality. D.) More important -- we have a very large output to meet our customers' big and continual orders. Reference: Bailey C, Day C. Traditional plants medicine as treatments for diabetes. Diabetes Care . 1989;12:553-564. Bell DR, Gochenaur K. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol . 2006 Apr;100(4):1164-70. Blumenthal M, Busse WR, Goldberg A, et al. The Complete German Commission E Monographs . Boston, Mass: Integrative Medicine Communications; 1998. Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine Expanded Commission E Monographs . Newton, Mass: Integrative Medicine Communications; 2000:18-19. Bomser J, Madhavi DL, Singletary K, et al. In vitro anti-cancer activity of fruit extracts from Vaccinium species. Planta Med . 1996;62:212–216. Cignarella A, Nastasi M, Cavalli E, et al. Novel lipid-lowering properties of Vaccinium myrtillus L . leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res . 1996;84(5):311-322. Gruenwald J, Brendler T, Jaenicke C, et al, eds. PDR for Herbal Medicines . 2nd ed. Montvale, NJ: Medical Economics Company Inc; 2000. Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev . 2001;6(2):141-166. Kramer JH. Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision—a systematic review of placebo-controlled trials. Surv Ophthalmol . 2004 Nov-Dec;49(6):618. Laplaud PM, Lelubre A, Chapman MJ. Antioxidant action of Vaccinium myrtillus extract on human low density lipoproteins in vitro: initial observations. Fundam Clin Pharmacol . 1997;11(1):35-40. Logan AC, Wong C. Chronic fatigue syndrome: oxidative stress and dietary modifications. Altern Med Rev . 2001;6(5):450-459. Magistretti NJ, Conti M, Cristini A. Antiulcer activity of an anthocyanidin from Vaccinium myrtillus . Arzneim-Forsch . 1988;38:686–690. Maatta-Riihinen KR, Kahkonen MP, Torronen AR, et al. Catechins and procyanidins in berries of vaccinium species and their antioxidant activity. J Agric Food Chem . 2005 Nov 2;53(22):8485-91. Muth ER, Laurent JM, Jasper P. The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity. Altern Med Rev . 2000;5(2):164-173. Norred CL, Finlayson CA. Hemorrhage after the preoperative use of complementary and alternative medicines. AANA J . 2000;68(3):217-220. Schulz V, Hansel R, Tyler VF. Rational Phytotherapy . Berlin, Germany: Springer-Verlag; 1998:193.

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