Hydroxypropyl Methyl Cellulose(HPMC)

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Hydroxypropyl Methyl Cellulose(HPMC)
Posting date : Oct 08, 2006
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Free Member Scince Aug 15, 2006
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29-
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Technical specification: 1. Quality standard: the product is in accordance with China Drug Code Issue 2000 or Usp XXIV and European XP standards. Index Type 60HD 65HD 75HD Methoxyl content(WT%) 28.0~30.0 27.0~30.0 19.0~24.0 Hydroxypropoxyl content(WT%) 7.0~12.0 4.0~7.5 4.0~12.0 Gelation temperature(℃) 58.0~64.0 62.0~68.0 70.0~90.0 PH value (1% solution,25℃) 4.0~8.0 Ash content(WT%) ≤0.5 Loss or drying (WT%) ≤5.0 Burnt residues(WT%) ≤1.5 Heavy metal(PPM) ≤20 Arsenic(PPM) ≤2 2. Viscosity:(2% solution at 20℃) Item Specification Range Low viscosity 5 3~7 10 8~12 15 13~18 Middle Viscosity 25 20~30 50 40~60 100 80~120 High Viscosity 4000 3500~5600 12000 10000~14000 Extra-high Viscosity 20000 17000~22000 25000 22000~28000 30000 27000~32000 40000 38000~42000 50000 47000~52000 60000 57000~62000 75000 72000~78000 3. Hydroxypropyl Methylcellulose type indication Physical Properties: 1. Out looking: HPMC is a white or light gray pellet or fibril power with odorless and tasteless. 2. Solubility: hardly dissolves in waterless ethanol, aether or acetone. Expands as to clear or slightly muddy colloid solution in cold water. It can dissolve in some organic solvents or some water-organic components. 3. Pellet: 100 screen passable rate is over 98.5%, 80 screen passable rate is 100%. 4. Density: 0.30-0.70g/cm3, Density: 1.26-1.31g/cm3 Properties 1. Water keeping ability: HPMC is a high water keeping agent whose drug level products are widely used in applications of food, cosmetic products and many other aspects. 2. Membranous ability: HPMC can be formed to transparent, tough, flexible film that can be reliably prevent grease from enter, During food storage, the properties are used to keep water and absorb oil. 3. Felting ability: HPMC is also a good felting ingredients, which is used to formed drug and food. Dissolving process HPMC will agglomerate when directly added to water and then dissolve. In this way it dissolves very slow and hard. Suggested methods as followers: 1. In hot water. Add water in container to 1/3 or 2/3 of its content. Heated to over 80℃.Because HPMC doesn't dissolve in hot water, it uniformly disperses in hot water. Add cool water or ice to the residual content, stir and cool down the mixture. 2. Powder combination. Mix HPMC with identical volume of other powder, dispersesthem sufficiently then add water to the mixture result HPMC dissolves without agglomeration. 3. Organic solvent wet. Dispersed or wet with organic solvents such as ethanol, glycol or oil, then add water can cause HPMC completely dissolves. Application Chemical ingredient HPMC made by Head Co.,Ltd. are widely used in food, cosmetic and other daily use chemical lines. Typical usage as following: 1. Medical durg. The product is a medical accessory material of may uses. It can be used for densifiers, dispersing agent, emulsifying agent, lubricator and former etc. It's used as an adhesive and coating film in tablets, increasing markedly rate of dissolution and release, and strengthen water proof for tablets and also be used as mixed dispersing agent, eye drop agent, controlled released matrix tablets. It is combined with other synthetic polymers and gel-type drug products to prevent ethanol separated from transparent gel drug while improve water keep ability. 2. Foodstuff HPMC can be directly used to food as effective emulsification agent, adhesive, thickening agent as well as can be used as packing materials. 3. Cosmetic. According to properties of HPMC, it can be used as thickening agent, emulsification agent, suspending agent, stabilizing agent, water retention agent, rheological behavior agent. Thus be used in all kinds of cosmetic products. Packing, transport and storage 20kg or 25 kg package in polyethylene bag or barrel with inner liners. Keep dry where good ventilated. Do not wet, and keep from sunshine when transport.

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