N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

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Product
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)a...
Posting date : Apr 28, 2026
Membership
Free Member Scince Dec 22, 2025
FOB Price
1
Min. Order Quantity
1kg
Supply Abillity
50000kg
Port
Beijing
Payment Terms
100% TT in Advance
Package
25kg/bags;10kg/bgs;1kg/bags
Keyword :
Category
Contact
Winnie Wang
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
JINLAN Brand
Model Number
182182-31-6
HS-CODE
-
Package & Delivery Lead Time
Package
25kg/bags;10kg/bgs;1kg/bags
Delivery Lead Time
7-14 workdays
Detailed Description
Product Name: Exatecan Intermediate / Exatecan Impurity 2
Synonyms: N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
CAS No.: 182182-31-6
Molecular Formula: C₁₃H₁₅FN₂O₂
Molecular Weight: 250.27 g/mol
Key Specifications:
  • Appearance: Off-white to gray solid
  • Melting Point: 200–210°C
  • Predicted Boiling Point: 550.1 ± 50.0°C
  • Predicted Density: 1.27 ± 0.1 g/cm³
  • Predicted pKa: 14.41 ± 0.20
  • Storage: 2–8°C, store in dark, dry, sealed conditions
  • Purity: ≥98% (determined by HPLC; full batch-specific COA provided)
Product Overview:
This compound is a key intermediate and reference impurity for Exatecan, a topoisomerase I inhibitor used in oncology. It is a common byproduct formed during the manufacturing process of Exatecan, and is widely used in pharmaceutical quality control, analytical method validation, and stability testing.
Applications:
  • Reference standard/impurity standard for Exatecan drug development
  • Used in pharmaceutical R&D, process optimization, and forced degradation studies
  • Applied in regulatory submissions (IND/ANDA/DMF) for oncology drugs
Additional Information:
  • Full analytical documentation (¹H NMR, LC-MS, elemental analysis, COA) available upon request
  • Custom synthesis and bulk production quantities are available
  • For research and laboratory use only; not intended for direct human administration.

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