Orforglipron Intermediate N-1 HCl salt

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Product
Orforglipron Intermediate N-1 HCl salt
Posting date : Apr 27, 2026
Membership
Free Member Scince Apr 24, 2026
FOB Price
1
Min. Order Quantity
1kg
Supply Abillity
50000kg
Port
Beijing
Payment Terms
100% TT in Advance
Package
25kg/bags;10kg/bgs;1kg/bags
Keyword :
Category
Contact
Winnie Wang
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
JINLAN Brand
Model Number
2212022-57-4
HS-CODE
-
Package & Delivery Lead Time
Package
25kg/bags;10kg/bgs;1kg/bags
Delivery Lead Time
7-14 workdays
Detailed Description
Product Name:
(S)-1-(4-Fluoro-1-methyl-1H-indazol-5-yl)-3-(2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1H-imidazol-2(3H)-one hydrochloride
Synonyms:
Orforglipron Impurity 52; (S)-1-(4-Fluoro-1-methyl-1H-indazol-5-yl)-3-(2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1,3-dihydro-2H-imidazol-2-one hydrochloride
CAS No.: 2212022-57-4
Molecular Formula: C₂₆H₂₆ClF₂N₇O
Molecular Weight: 525.99 g/mol

Key Specifications & Properties:
  • Appearance: Solid (typical for high-purity pharmaceutical reference standards)
  • Stereochemistry: Single (S)-enantiomer, high chiral purity (≥98% ee typical)
  • Purity: ≥98% (determined by HPLC; full batch-specific COA provided)
  • Storage: Store at -20°C under inert atmosphere, protect from light and moisture
  • Form: Hydrochloride salt, offering improved stability and solubility characteristics

Application & Use Case:
This compound is an impurity reference standard for Orforglipron (Olagliflon), an oral non-peptide small-molecule GLP-1 receptor agonist developed for the treatment of type 2 diabetes and obesity. It is widely used in:
  • Pharmaceutical quality control and analytical method validation (HPLC, LC-MS)
  • Stability testing and forced degradation studies for Orforglipron
  • Regulatory submissions (IND/ANDA/DMF) requiring impurity identification and characterization
  • R&D and manufacturing process validation for GLP-1 drug candidates

Additional Information:
  • Full analytical documentation available: HPLC, chiral HPLC, ¹H NMR, ¹³C NMR, LC-MS, elemental analysis, and COA
  • Custom synthesis and bulk production quantities available upon request
  • For research and laboratory use only; not intended for human or veterinary therapeutic administration.

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