Orforglipron Intermediate N-1

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Product
Orforglipron Intermediate N-1
Posting date : Apr 27, 2026
Membership
Free Member Scince Apr 24, 2026
FOB Price
1
Min. Order Quantity
1kg
Supply Abillity
50000kg
Port
Beijing
Payment Terms
100% TT in Advance
Package
25kg/bags;10kg/bgs;1kg/bags
Keyword :
Category
Contact
Winnie Wang
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
JINLAN Brand
Model Number
2212022-56-3
HS-CODE
-
Package & Delivery Lead Time
Package
25kg/bags;10kg/bgs;1kg/bags
Delivery Lead Time
7-14 workdays
Detailed Description
Product Name:
1-[(4S)-2-(4-Fluoro-3,5-dimethylphenyl)-4,5,6,7-tetrahydro-4-methyl-2H-pyrazolo[4,3-c]pyridin-3-yl]-3-(4-fluoro-1-methyl-1H-indazol-5-yl)-1,3-dihydro-2H-imidazol-2-one
Synonyms:
Orforglipron Intermediate, Olagliflon Intermediate Impurity 18
CAS No.: 2212022-56-3
Molecular Formula: C₂₆H₂₅F₂N₇O
Molecular Weight: 501.53 g/mol

Key Specifications & Properties:
  • Appearance: Solid (typical for high-purity pharmaceutical intermediates)
  • Predicted Boiling Point: 650.0 ± 65.0 °C
  • Predicted Density: 1.45 ± 0.1 g/cm³
  • Predicted pKa: 8.39 ± 0.40
  • Stereochemistry: Single (4S)-enantiomer, high chiral purity (≥98% ee typical)
  • Purity: ≥98% (determined by HPLC; full batch-specific COA provided)
  • Storage: Store at -20°C under inert atmosphere, protect from light and moisture

Application & Use Case:
This compound is a key synthetic intermediate and impurity reference standard for Orforglipron (Olagliflon), a novel oral GLP-1 receptor agonist developed for the treatment of type 2 diabetes and obesity. It is widely used in:
  • Pharmaceutical process development and scale-up for GLP-1 drug candidates
  • Analytical method validation (HPLC, LC-MS, chiral chromatography)
  • Stability testing and forced degradation studies
  • Regulatory submissions (IND/ANDA/DMF) requiring intermediate and impurity characterization

Additional Information:
  • Full analytical documentation available: HPLC, chiral HPLC, ¹H NMR, ¹³C NMR, LC-MS, elemental analysis, and COA
  • Custom synthesis and bulk production quantities available upon request
  • For research and laboratory use only; not intended for human or veterinary therapeutic administration.
 

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