Orforglipron Intermediate M-3

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Product
Orforglipron Intermediate M-3
Posting date : Apr 27, 2026
Membership
Free Member Scince Apr 24, 2026
FOB Price
1
Min. Order Quantity
1kg
Supply Abillity
50000kg
Port
Beijing
Payment Terms
100% TT in Advance
Package
25kg/bags;10kg/bgs;1kg/bags
Keyword :
Category
Contact
Winnie Wang
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
JINLAN Brand
Model Number
3047556-95-3
HS-CODE
-
Package & Delivery Lead Time
Package
25kg/bags;10kg/bgs;1kg/bags
Delivery Lead Time
7-14 workdays
Detailed Description
Product Name:
1H-Indole-2-carboxamide, 1-[(1S,2S)-1-[(Z)-amino(hydroxyimino)methyl]-2-methylcyclopropyl]-N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-
Synonyms:
Orforglipron Intermediate, Olagliflon Intermediate Impurity, Orforglipron Intermediate Hydroxyamidine Derivative
CAS No.: 3047556-95-3
Molecular Formula: C₂₈H₃₄N₄O₃
Molecular Weight: 474.6 g/mol

Key Specifications & Properties:
  • Appearance: White to off-white solid (typical for high-purity pharmaceutical intermediates)
  • Predicted Boiling Point: 660.7 ± 65.0 °C (at 760 Torr)
  • Predicted Density: 1.277 ± 0.14 g/cm³ (at 25 °C, 760 Torr)
  • Predicted pKa: 14.66 ± 0.40
  • Stereochemistry: Multi-chiral center (1S,2S,4S) with defined (Z)-oxime geometry, ≥98% enantiomeric purity
  • Purity: ≥98% (determined by HPLC; full batch-specific COA available)
  • Storage: Store at -20°C under inert gas; protect from light, moisture, and prolonged air exposure

Application & Use Case:
This compound is a key synthetic intermediate and impurity reference standard for Orforglipron (Olagliflon), a novel oral GLP-1 receptor agonist under clinical development. It is used in:
  • Pharmaceutical process development and scale-up
  • Analytical method validation (HPLC, LC-MS, chiral chromatography)
  • Stability testing and forced degradation studies
  • Regulatory submissions (IND/ANDA/DMF) requiring impurity identification and characterization

Additional Information:
  • Full analytical data available: HPLC, ¹H NMR, ¹³C NMR, LC-MS, elemental analysis, and COA
  • Custom synthesis and bulk manufacturing quantities available upon request
  • For research and laboratory use only; not intended for human or veterinary therapeutic administration.

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