P-Methoxyl methyl cinnamate

P-Methoxyl methyl cinnamate is a synthetic fragrance whose appearance is white crystalline solid and insoluble in water, but soluble in organic solvents such as ethanol. It should be stored in a cool place in a sealed place.

 

As an kind of essence, Ethyl 4-methoxycinnamate is mainly used in food additives, spices, in cosmetics, as a pharmaceutical intermediate for UV protective absorbent.

 

Studies have shown that ultraviolet light in the 280-320 nm region is easy to cause sunburn and produce "sunlight dermatitis" such as erythema and blisters. Ethyl 4-MethoxycinnaMate has a wide and strong absorption in the 280-320 nm region, is non-irritating to the skin, and has good safety. It is an ideal sunscreen agent, and the octyl esters are used in the United States, EU countries and China. In the first place or in the forefront, ethyl ester also has good absorption in this area, and its absorption rate is high. It is another commonly used sunscreen. It also has a broad-spectrum antifungal effect and is the main active ingredient of antifungal in rhizome of Rhizoma Curcuma. And after the improvement, the operation of Ethyl 4-methoxycinnamate is more convenient, the side reaction is smaller, and the environment is less polluted. It is a new type of flavor and fragrance.

 

Product configuration and UV absorption:

The intermediate p-methoxycinnamic acid is a trans-form, because the phenyl and carboxyl groups in the trans-form are far apart, lower than the cis-in vivo, and more stable; the esterification reaction does not involve double bonds, so the double bond structure The type does not change, and ethyl p-methoxycinnamate is also a trans form. The NMR data of the two also confirmed that the product is a trans structure, and the chemical shift of the double bond hydrogen is consistent with the data calculated by the empirical rule.