3,3-Diphenylpropionic Acid

Synonym	3,3-Diphenylpropionic acid; 3,3-Diphenylpropanoic acid; 606-83-7; Benzenepropanoic acid, .beta.-phenyl-; 3,3-Diphenyl-propionic acid
CAS	606-83-7
Formula	C15H14O2
Formula Weight	226.27
Physical Form	Crystalline Powder
Melting Point	157 degree C
Boiling Point	365 degree C
Flash Point	113 degree C
Inhalation	May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated
Water solubility	Slightly soluble
Appearance	White to light yellow solid
Ingestion	May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated
Stability	Stable under normal temperatures and pressures
Decomposition	Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide
Incompatibilities	Oxidizing agents
Storage	Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances

Safety and Handling:

GHS H Statement:

May cause respiratory irritation.

Causes serious eye irritation.

Causes skin irritation.

GHS P Statement:

Avoid breathing dust/fume/gas/mist/vapors/spray.

IF ON SKIN: Wash with plenty of soap and water.

Wear protective gloves/protective clothing/eye protection/face protection.

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Applications:

Separation of 3,3-Diphenylpropionic acid on Newcrom R1 HPLC column

3,3-Diphenylpropionic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Phenylpropanoic acid is used in the food industry to preserve and maintain the original aroma quality of frozen foods. It can also be used to add or restore original color to food. Shelved foods are protected from microorganism by adding phenylpropanoic acid to prevent deterioration to the food by microorganisms as well as acting as an antioxidant to prolong shelf life foods. This compound is used as a sweetener as well to sweeten food and can be found in table top sweeteners. It can also act as an emulsifier, to keep oil and water mixtures separated. Phenylpropanoic acid is also added to food for technological purposes in a wide variety including manufacturing, processing, preparation, treatment, packaging, transportation or storage, and food additives. It also provides flavorings for ice cream, bakery, and confectionery.