Quick Detail
Place of Origin
Brand Name
SUPER STEROIDS
Model Number
106612-94-6
HS-CODE
29-
Package & Delivery Lead Time
Package
2mg/vial or as your request
Delivery Lead Time
4-6 working days
Detailed Description
98% Polypeptide Hormones GLP-1 CAS 106612-94-6 Glucagon-Relatedpeptide 1 For The Treatment of Type 2 Diabetes Mellitus
Quick Details:
# GLP-1 (7-37) Acetate
# Sequence:His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
# Alias : 7-37-Glucagon-likepeptide I (human);Glucagon-relatedpeptide 1 (Rana catesbeiana),3-L-glutamicacid-10-L-valine-16-glycine-17-L-glutamine-23-L-isoleucine-24-L-alanine-27-L-valine-31-glycine-32-de-L-lysine-
# Cas No.: 106612-94-6
# Molecular Formula: C151H228N40O47
# M.S.:
# Molecular Weight: 3355.74
# Purity (HPLC): 98.0%
# Appearance: White powder
# Single Impurity (HPLC): 1.0%
# Amino Acid Composition: 10% of theoretical
# Peptide Content (N%): 80% (by %N)
# Water Content (Karl Fischer): 6.0%
# Acetate Content (HPIC): 15.0%
# Grade : Pharmaceutical Grade
# Storage: Closed, below 2 ~ 8 preservation
# Manufacturer : Hezhong
# Usage : GLP-1 can obviously improve the blood glucose in type 2 diabetes animal models or patients through a variety of mechanisms, which promote the regeneration and repair of islet beta cells, increase the number of beta cells is particularly significant role, provides a very good prospect for the treatment of type 2 diabetes mellitus.
Description:
Glucagon like peptide -1 (GLP-1) is a brain gut peptides secretion ileal endocrine cells, at present mainly as a target for type 2 diabetes drug action. Because GLP-1 can reduce the inhibition of gastric emptying, intestinal peristalsis, thus helps to control food intake, weight loss. Prospective placebo in 19 cases of obese patients in control, random, double-blind, crossover trial, GLP-1 subcutaneous injection can increase the patients with postprandial satiety, and make each meal diet weight average reduction of 15%. But because GLP-1 is a polypeptide, cannot be administered orally is a major shortcoming.
GLP-1 consists of proglucagon gene expression in pancreatic alpha cells, the main product, expression of proglucagon gene is glucagon, and in the intestinal mucosa of L cells, prohormone converting enzyme (PC1) the proglucagon peptide sequence in the carboxyl end shear, i.e. GLP-1. GLP-1 has 2 kinds of biological active forms, respectively GLP-1 (7-37) and GLP-1 (7-36) amide, both of which only one amino acid sequences different, cyclic activated about 80% GLP-1 from the GLP-1 (7-36 [1,2]) amide.
Application:
Effect of GLP-1 GLP-1 can protect beta cells can act on the pancreatic beta cells, promote the synthesis of insulin, insulin gene transcription and secretion and can stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of pancreatic beta cells, increase the number of beta cell of islet [2-5]. In addition, GLP-1 also can be applied to the pancreatic alpha cells, strongly inhibit the release of glucagon, and act on the islet delta cells, promote the secretion of somatostatin, somatostatin cells and can be used as a paracrine hormone involved in the inhibition of glucagon.
GLP-1 with glucose concentration dependent hypoglycemic effect, i.e. only rise in glucose levels under the condition of GLP-1, only play a hypoglycemic effect, but in normal blood sugar levels, caused no further decrease. The glucose concentration dependence of the GLP-1 is its hypoglycemic properties of clinical application safety of foundation and security, thereby avoiding people may cause severe hypoglycemia in patients with existing drug treatment for diabetes and scheme of worry.
In addition, GLP-1 also has many other biological characteristics and functions, for example, GLP-1 might play a lipid-lowering, antihypertensive effect, so as to have a protective effect on the cardiovascular system; it can also by acting on central reinforcement learning and memory function, protect the nerve.
Specifications :
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Product name | GLP-1 (7-37) Acetate |
Appearance | White Powder |
Assay | 98% |
Molecular formula | C151H228N40O47 |
Molecular weight | 3355.74 |
Package | 2mg/vial or as your request |
Shipping | Fast and secure shipping by DHL,EMS,UPS,TNT, FedEx.. |
Shipping leading time | Within 12 hours after receiving the payment |
Payment Terms | Western Union, Money Gram , T/T, PayPal |
Price | Negotiable |
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Competitive Advantages:
# Rich experience. We specialize in this field for over 14 years,our steroids and hormones have been exported to overseas including Europe,Africa,Asia, Americas and other countries. We have received very good feedbacks from our customers,and established stable relationship of cooperation.
# Great quality, purity and favorable rate . Good quality is one of our secret success, welcome to try testing orders.
# Safest and fastest delivery. We have sufficient stock,so we can arrange shipment within 12hours upon the receipt of payment.Tracking number would be informed quickly after shipment.
# Special way to deliver 2mg to 100mg products at a time. We offer melting powder into liquid service.And ship the liquid in special bottles.
# Good after-sales service.
# Everything is for customers. Our products and services will focus on the largest customer demand,We hold the greatest enthusiasm and sincere cooperation with each customer.
# All in all, high quality, best service, secure shipping and competitive price are our perpetual pursuit.
Keywords :
HGH Steroid Hormone
Polypeptide Hormones
Health Supplement
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China [CN] 
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