Quick Detail
Place of Origin
Brand Name
PooChun
Model Number
171596-29-5
HS-CODE
29-
Package & Delivery Lead Time
Package
1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
Delivery Lead Time
1-3days after payment
Detailed Description
Tadalafil Medicine Raw Material For pulmonary arterial hypertension PDE5 Inhibitor C22H19N3O4
Description
Tadalafil is cyclic guanosine phosphate ( cGMP ) specific phosphodiesterase 5 ( PDE5 ) selectivity and reversible inhibitor, when sexual stimulation leads to partial release nitric oxide, tadalafil inhibit PDE5, make the penis sponge body cGMP level, resulting in smooth muscle relaxation, blood flow to the penis, produce an erection, such as asexual stimulation.
Selectivity compared with other PDE5 inhibitors
Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme. These drugs also inhibit other PDE enzymes. Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil. Some sildenafil users see a bluish tinge and have a heightened sensitivity to light because of PDE6 inhibition. Sildenafil and vardenafil also inhibit PDE1 more than tadalafil. PDE1 is found in the brain, heart, and vascular smooth muscle. It is thought that the inhibition of PDE1 by sildenafil and vardenafil leads to vasodilation, flushing, and tachycardia. Tadalafil inhibits PDE11 more than sildenafil or vardenafil. PDE11 is expressed in skeletal muscle, the prostate, the liver, the kidney, the pituitary gland, and the testes. The effects on the body of inhibiting PDE11 are not known.
Applications
1. Like its predecessor Viagra, Cialis is used to treat erectile dysfunction in men.
2. One of the more embarrassing side effects of post - cycle - therapy is the decreased libido caused by the sudden absence of exaggerated testosterone levels in the body, often leading to ED. If you cann't get it up after your cycle, get the pill.
3. Tadalafil is the raw material of cialis.
4. Cialis is a kind of male sex enhancer drug.
5. Cialis is much longer lasting than Viagra. Effects can be felt anywhere between 36-48 hours.
6. Cialis works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function
Specification
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Test Items | Specification | Test Results |
Appearance | White powder | Conforms |
Test method | High pressure liquid chromatography(HPLC) | Conforms |
Melting Point | 300303 | 301.5-302.6 |
Loss on drying | 0.5% | 0.24% |
Heavy metals(Pb) | 20ppm | 7.5ppm |
Residue on ignition | 0.1% | 0.08% |
Relative substance | 1.0% | 0.145% |
Assay (on dried basis) | 98.5% | 99.53% |
Conclusion | The product conform to USP 32 |
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Chemistry
Tadalafil is an annulated 2,5- diketopiperazine. It is also a 1,2,3,4- tetrahydro - - carboline.
Tadalafil can be synthesized starting from ( D ) - tryptophan methyl ester and piperonal via a Pictet Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring:
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