t - boc - N - amido - dPEG3 - amine Is For ADC Research

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References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG products. Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting system with Streptavidin Mutants, D. Scott Wibur, Steven I. Park, Ming-Kuan Chyan, Feng Wan, Donald K. Hamlin, Jaideep Shenoi, Yukang Lin, Shani M. Wilbur, Franz Buchegger, Anastasia Pantelias, John M. Pagel, and Oliver W. Press. Bioconjugate Chem. 2010, 21 (7), pp 12251238. July 2, 2010. DOI: 10.1021/bc100030q. Novel Nanoassemblies Composed of SqufalenoylPaclitaxel Derivatives: Synthesis, Characterization, and Biological Evaluation, Franco Dosio, L. Harivardhan Reddy, Annalisa Ferrero, Barbara Stella, Luigi Cattel, and Patrick Couvreur. Bioconjugate Chem. 2010, 21 (7), pp 13491361. July 2, 2010. DOI: 10.1021/bc100154g. A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis. Daniel J. Wilson, Ce Shi, Benjamin P. Duckworth, Joseph M. Muretta, Ujjini Manjunatha, Yuk Y. Sham, David D. Thomas, and Courtney C. Aldrich. Analytical Biochemistry. 2011, 416 (1) pp 27-38. September 2011. DOI:10.1016/j.ab.2011.05.003. Thiol-Mediated Anchoring of Ligands to Self-Assembled Monolayers for Studies of Biospecific Interactions. Kunal V. Gujraty, Randolph Ashton, Sridhar R. Bethi, Sandesh Kate, Christopher J. Faulkner, G. Kane Jennings, and Ravi S. Kane. Langmuir. 2006, 22 (24) pp 1015710162. October 19, 2006.DOI: 10.1021/la0621463. Design, Synthesis, and Validation of a Branched Flexible Linker for Bioactive Peptides. Martina E. Bowen, Yasunari Monguchi, Rajesh Sankaranarayanan, Josef Vagner, Lucinda J. Begay, Liping Xu, Bhumasamudram Jagadish, Victor J. Hruby, Robert J. Gillies, and Eugene A. Mash. J. Org. Chem. 2007, 72 (5) pp 16751680. February 6, 2007. DOI: 10.1021/jo062276g. Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4. Orzala Sharif, Huiyong Hu, Heath Klock, Eric N. Hampton, Edward Nigoghossian, Mark W. Knuth, Jason Matzen, Paul Anderson, Richard Trager, Tetsuo Uno, Richard J. Glynne, Sassan M. Azarian, Jeremy S. Caldwell , Achim Brinker. Analytical Biochemistry. 2009, 392, (2) PP 162168. September 15 , 2009. doi.org/10.1016/j.ab.2009.05.038. Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand. Wenhao Liu, Andrew B. Greytak, Jungmin Lee, Cliff R. Wong, Jongnam Park, Lisa F. Marshall, Wen Jiang, Peter N. Curtin, Alice Y. Ting, Daniel G. Nocera, Dai Fukumura, Rakesh K. Jain and Moungi G. Bawendi. J. Am. Chem. Soc. 2010, 132 (2) pp 472483. December 21, 2009. DOI: 10.1021/ja908137d. HAZARDS INDENTIFICATION OSHA/HCS status: While this material is not considered hazardous by theChina Hazard Communication Standard, this SDS contains valuable information critical to the safe handling and proper use of the product. This SDS should be retained and available for employees and other users of this product. Classification of the substance or mixture: Not classified. GHS label elements Signal word: No signal word. Hazard statements: No known significant effects or critical hazards. Precautionary statements Prevention: Not applicable. Response: Not applicable. Storage: Not applicable. Disposal: Not applicable. Hazards not otherwise classified: None known. SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS CAS No.: 194920-62-2 Chemical Formula: CHNO Molecular Weight: 320.43; single compound Assay: >90% Synonym: N-t-boc-4,7,10-trioxatridecane-13-amine or tert-butyl N- (13-amino-4,7,10-trioxatridecyl)carbamate. FIRST-AID MEASURES Description of necessary first aid measures Eye contact: Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. Skin contact: Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Ingestion: Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. Most important symptoms/effects, acute and delayed Potential acute health effects Eye contact: No known significant effects or critical hazards. Inhalation: No known significant effects or critical hazards. Skin contact: No known significant effects or critical hazards. Ingestion: No known significant effects or critical hazards. Over-exposure signs/symptoms Eye contact: No specific data. Inhalation: No specific data. Skin contact: No specific data. Ingestion: No specific data.

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