Exemestane Aromasin

 

 

 

 

 

 

Exemestane is a steroidal Aromatase Inhibitor (AI) that is most commonly known as Aromasin. In fact, the Aromasin brand name is the only pharmaceutical grade brand of the Exemestane AI due to the tight patent Upjohn has maintained on the product. While tightly controlled by the pharmaceutical giant, Aromasin is available in numerous countries around the globe. Aromasin was first released on the U.S. market in 2000 after shortly gaining FDA approval a few months prior in 1999. The primary purpose of use as with most AI's would be to combat breast cancer in post-menopausal women. Shortly after, the AI would begin to gain a lot of popularity among anabolic steroid users for its ability to protect against estrogenic related side effects. This action is very similar to the older and more popular AI's in Arimidex and Femara It would also gain a fair amount of popularity in Post Cycle Therapy (PCT) plans among steroid users. It was not the first AI to gain such popularity but would prove to be a little more advantageous for this purpose than most AI'sAromasin is officially classified as a steroidal suicide Aromatase Inhibitor, and carries the ability to inhibit the aromatase enzyme, which is responsible for the production or conversion of testosterone to estrogen. Aromasin has the ability to block aromatization, which in turn inhibits the production of estrogen, and thereby lowers the body's serum estrogen levels. This will prove useful to breast cancer patients as breast cancer often feeds off the estrogen hormone. It will also prove useful to the anabolic steroid user.Many anabolic steroids have the ability to increase estrogen levels due to the aromatase process, specifically the conversion of testosterone to estrogen. This can lead to gynecomastia and water retention. Excess water retention can also promote high blood pressure when it becomes severe. Steroids that do not carry a strong estrogenic nature can also cause these effects, most notably gynecomastia if they carry a progestin nature. A prime example would be Nandrolone, which while it aromatizes only does so at 20% the rate of testosterone. However, it also carries a strong progestin nature, and progesterone has been well noted for carrying the ability to stimulate the estrogenic mechanism in the mammary tissue. By administering Aromasin during the use of anabolic steroids, this will inhibit the aromatase process, lower estrogen levels and protect the individual from estrogenic side effects. How effective is Aromasin? The product claims on average to have the ability to lower serum estrogen levels by 85%.Applications:In a therapeutic setting, by blocking the aromatase enzyme, Aromasin actively prohibits the cancer from feeding off the hormone necessary to its survival. It has been proven highly effective for this purpose, but only after the use of the Selective Estrogen Receptor Modulator (SERM) Nolvadex (Tamoxifen Citrate) has failed. While effective, it is also not as commonly used as Arimidex for this purpose as Arimidex largely maintains itself as the primary AI in breast cancer treatment not only among post-menopausal women but in a host of breast cancer scenarios. Then we have Aromasin as an anti-estrogen for the anabolic steroid user. By understanding its functions and traits you should already understand the effects of Aromasin in this regard. Excess estrogen levels can promote gynecomastia and water retention and possibly high blood pressure as a secondary issue. However, keep in mind such effects are not possible with all anabolic steroids, primarily it must carry an estrogenic nature, it must be able to aromatize to lead to such effects or carry a progesterone nature. Testosterone is the primary aromatizing steroid, but testosterone derived steroids like Dianabol can also promote strong estrogenic action. Then we have the Boldenone (Equipoise) hormone, and while it only aromatizes at 50% the rate of testosterone, this is still enough to cause an estrogen buildup in some. Finally, we're left with 19-nortestosterone (19-nor) anabolic steroids. 19-nor compounds will primarily include all forms of Nandrolone and Trenbolone. As discussed Nandrolone aromatizes at 20% the rate of testosterone, but it also carries a very strong progestin nature. This can promote a fair amount of estrogenic activity in many men. As for Trenbolone, it does not aromatize at all, but its moderately strong progestin nature can make gynecomastia a possibility depending on the individual's sensitivity. When use is coupled with an aromatizing steroid, this will greatly enhance the odds of gynecomastia. Regardless of the steroid in question, Aromasin can offer protection from the estrogenic effects.An important note: Aromasin will have no affect on dihydrotestosterone (DHT) derived anabolic steroids as they do not convert to estrogen. Such steroids cannot lead to gynecomastia or excess water retention; it is impossible. The exception would be Anadrol, while a DHT derivative, it carries with it a strong estrogenic nature. However, while estrogenic action is present, the hormone does not aromatize, meaning there is no aromatization for Aromasin to inhibit. The use of an AI will not affect the estrogenicity of Anadrol. For protection from such a steroid, the individual will need to inhibit activation of the estrogenic mechanism, and this will make SERM's the first line of defense.

 

 

 

 

 

Functions:Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive and can be treated with drugs that block the effects of these hormones.In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.

 

Effect:Aromasin is a suicidal aromatase inhibitor (AI), meaning it permanently disables the aromatase enzyme once it binds to it. In plain English, Aromasin will prevent the currently bound enzymes from rebounding, which is what separates this drug from letrozole or arimidex. When you use other AI's, they temporarily stop estrogen from aromatizing, but when you stop taking them those same enzymes can rebound causing what is known as 'estrogen rebound'. This explains why some anabolic steroid users experience gynecomastia (bitch tits) after cycle when using other AI's. Studies on breast cancer patients have shown aromasin reduced estrogen levels up to 85%.Athletes commonly buy Aromasin to aid in their performance enhancement in conjunction with anabolic steroids. As an aromatase inhibitor Aromasin reduces the amount of estrogen in the body and this is precisely the reason any athlete will buy Aromasin. Make no mistake, Estrogen is essential to our overall well-being but this hormone is also damaging to a physique when levels become too high.When our estrogen levels are too high we will have difficulty in maintaining a lean and hard physique and if were using anabolic steroids a host of negative side-effects can rear their heads.This is why many steroid users buy Aromasin and with proper use they eliminate the potential problems associated with estrogen build up.Dosage:This is dependent on the individual and, also, the amount of aromatizing compounds the person is running. Generally, a good starting dose is 12.5mg ED (every day) or 25mg EOD (every other day). The user must utilize blood work to see how their body is reacting at the starting dosage they choose and then adjust as needed. Experienced anabolic steroid users will usually find a dose they like and stick to it with no problems. As I said already, if you start noticing joint issues then the dose should be lowered; on the other hand, if you start noticing any estrogen related sides, such as puffy or sensitive breasts or water retention, it's time to increase the dosage.

How to storage:1.It is recommended to store ai the room temperature between 2-8 degrees C.2.Keep the drug away from direct sunlight, heat and moistrue.3.Do not let the drug at the sight and reach of children.How to Place Order?

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