Human Hepatic Stellate Cells

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Product
Human Hepatic Stellate Cells
Posting date : Jul 13, 2017
Membership
Free Member Scince Jul 13, 2017
FOB Price
1
Min. Order Quantity
1
Supply Abillity
100
Port
1
Payment Terms
credit card/ cash/
Package
1
Keyword :
Category
Contact
Chelsea Clark
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Product Detail
Company Info
 
Quick Detail
Place of Origin
United States [US]
Brand Name
Creative Bioarray
HS-CODE
2805-12
Package & Delivery Lead Time
Package
1
Detailed Description
Hepatic stellate cells (HSteC) are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, HSteC transform into myofibroblast-like cells and are the major source of type I collagen in the fibrotic liver. Beyond these feature, HSteC have been implicated as regulators of hepatic microcirculation via cell contraction, and in disease states, in the pathogenesis of intrahepatic portal hypertension. Proliferation and migration of HSteC and expression of chemokines are involved in the pathogenesis of liver inflammation and fibrogenesis. HSteC possess voltage-activated calcium current, express the low affinity nerve growth factor receptor p75, and undergo apoptosis in response to nerve growth factor stimulation. Therefore, the new insight into the molecular regulation of HSteC activation will lead to therapeutic approaches in treatment of hepatic fibrosis in the future, and could lead to reduced morbidity and mortality in patients with chronic liver injury. 

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