GW501516

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Product
GW501516
Posting date : Jul 10, 2017
Membership
Free Member Scince Jan 03, 2017
FOB Price
negotiation
Min. Order Quantity
20g
Supply Abillity
enough
Port
shanghai
Payment Terms
T/T
Package
Foil bag
Keyword :
Category
Contact
Sara
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
fantike
HS-CODE
2801-10
Package & Delivery Lead Time
Package
Foil bag
Detailed Description
Name: GW501516
CAS No.: 317318-70-0
Appearance: white powder
Purity : ≥ 99%
Molecular formula: C21H18F3NO3S2
Molecular weight: 453.50
Detail:
GW501516 also known as GW-501,516, GW1516 and GSK-516.It is a selective agonist (activator) of the PPARδ receptor. It was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases.
GW501516 is a synthetic ligand of PPARδ and belongs to the phenoxyacetic acid derivative. After binding to GW501516, activated PPARδ forms a heterodimer with 9-cis retinoid receptor (RXR) And then identify the peroxisome proliferator response element (PPRE) upstream of the target gene promoter to regulate gene transcription, translation and biological effects downstream of the target gene.
GW501516 inhibits apoptosis of ox-LDL or high glucose-induced HUVECs and attenuates the inhibitory effect of ox-LDL or high glucose on HU-VECs activity.

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