Beloranib CAS 251111-30-5,529511-79-3

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Beloranib CAS 251111-30-5,529511-79-3
Posting date : Aug 26, 2016
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Free Member Scince Aug 26, 2016
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1
Min. Order Quantity
1g
Supply Abillity
1000kg
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Hong Kong
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Paypal,Bitcoin,WesternUnion,Webmoney,Escrew
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custom
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Company Info
 
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Place of Origin
China [CN]
Brand Name
roughchem
Model Number
02
HS-CODE
2801-20
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custom
Detailed Description
Beloranib  CAS 251111-30-5,529511-79-3
Beloranib is a former drug candidate for the treatment of obesity. It was discovered by CKD Pharmaceuticals and its clinical development was led by Zafgen.Drug development for the product was halted in 2016.
Beloranib, an analog of the natural chemical compound fumagillin, is an inhibitor of the enzyme METAP2. It was originally designed as angiogenesis inhibitor for the treatment of cancer.However, once the potential anti-obesity effects of METAP2 inhibition became apparent, the clinical development began to focus on these effects and beloranib has shown positive results in preliminary clinical trials for this indication.
A Phase I trial was published in 2013,finding a dose that led to weight loss in obese women in comparison to placebo. Results from a Phase II clinical trial for obesity were promising with clinically meaningful weight loss and improvements in cardiometabolic risk factors in the treated group. Zafgen continued with a Phase III trial for Prader–Willi syndrome.
In December 2015, Zafgen halted the Phase III clinical trial of beloranib for Prader–Willi syndrome after a second patient death in order to determine whether the deaths were treatment-related.After discussions with the Food and Drug Administration indicated that the obstacles to gaining approval were insurmountable, product development for beloranib was ended.

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