WZ 4002 | Global Trade leader ecrobot

Product

WZ 4002

Posting date : Jun 24, 2016

Click enlarge Image

Membership

Free Member Scince Jun 24, 2016

FOB Price

2.8

Min. Order Quantity

100g

Supply Abillity

100kg

Port

Shenzhen

Payment Terms

We accept T/T, L/C, Western Unoin, Money Gram, and Bitcoin as payment only.

Package

Aluminum Foil Bags or Fiber Drum.

Keyword :

Pharmaceutical Raw M

Category

CHEMICAL | Inorganic | Other inor | Inorganic

Contact

Jason Edwards

0 likes

Product Detail

Company Info

Quick Detail

Place of Origin

China [CN]

Brand Name

NEWBIO

Model Number

1213269-23-8

HS-CODE

2811-29

Package & Delivery Lead Time

Package

Aluminum Foil Bags or Fiber Drum.

Delivery Lead Time

8days

Detailed Description

Small Molecular Raw API Powder WZ 4002(CAS# 1213269-23-8)Chemical Information

Product Name	WZ4002
Molecular Formula	C25H27ClN6O3
Molecular Weight	494.18
Storage	Store at -20°C
Targets	EGFRL858R EGFRL858R/T790M
IC50	2 nM 8 nM

Description

WZ4002 is a novel, mutant-selective inhibitor of EGFR for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM.

WZ4002 inhibits other EGFR genotypes E746_A750 and E746_A750/T790M with IC50 of 2 and 6 nM. Besides, WZ4002 suppresses widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines and WZ4002 prevents of EGFR phosphorylation in NIH-3T3 cells expressing different EGFR T790M mutant alleles. For WZ4002, kinases that exhibited greater than 95% inhibition relative to the DMSO control at 10 μM are selected for measurement of their dissociation constants. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR compared to WZ3146. WZ4002 is 100-fold less effective at inhibiting phosphorylation of WT EGFR compared to the quinazoline inhibitors. Similarly, WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 . In addition, the phosphorylated EGFR of Src TKI-resistant H1975 cells, as well as HCC827 cells, is completely suppressed by the third generation EGFR TKI, WZ4002.

Application

Treatment with WZ4002 completely inhibited the growth of PC-9/Vec tumors, whereas treatment with E7050 did not (Fig. A). Treatment with either agent a lone slightly suppressed the growth of PC- 9/HGF#5 t umor s ( Fig. B). Importantly, the combination of WZ4002 and E7050 reduced the size of PC-9/HGF#5 tumors(Fig.B).These results suggest that HGF can induce resistance to WZ4002 in vivo and that this resistance can be overcome by E7050. In the second model, the growth of tumors induced by H1975 cells, which carry a T790M second mutation, was inhibited by WZ4002 (Fig. C), In the third model, in which resistance was induced by Met amplification, monotherapy with either WZ4002 or E7050 partially inhibited the growth of HCC827ER tumors(Fig. D)Report:

Product name	WZ4002
CAS NO.	1213269-23-8
Synonyms	WZ4002
Category	Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
Purity	99% WZ4002
Appearance	WZ4002 powder
Shelf life	2 years
Usage	WZ4002 is an anticancer drug.
Storage	WZ4002 should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Note	WZ4002 for R&D use only.

FEATURED PRODUCT:

Wuhan Newbio Pharm-tech Co., Ltd.
S#	CAS No.	Product Name	S#	CAS No.	Product Name
1	86639-52-3	7-Ethyl-10-Hydroxycamptothecin	25	183321-74-6	Erlotinib
2	154229-18-2	Abiraterone Acetate	26	183319-69-9	Erlotinib Hydrochloride
3	50-76-0	Actinomycin D	27	159351-69-6	Everolimus
4	106941-25-7	Adefovir	28	56296-78-7	Fluoxetine Hydrochloride
5	850140-72-6	Afatinib	29	184475-55-6	Gefitinib Hydrochloride
6	330784-47-9	Avanafil	30	136572-09-3	Irinotecan Hydrochloride TriHydrate
7	319460-85-0	Axitinib	31	1441674-54-9	Ledipasvir(Acetone)
8	1421373-66-1	AZD-9291 (Mesylate)	32	191732-72-6	Lenalidomide
9	123524-52-7	Azelnidipine	33	21672	Methotrexate
10	863031-21-4	Azilsartan Medoxomil	34	76144-81-5	Mildronate
11	179324-69-7	Bortezomib	35	474645-27-7	Monomethyl Auristatin E
12	357336-20-0	Brivaracetam	36	63121-00-6	Oxaliplatin
13	842133-18-0	Canagliflozin	49	33069-62-4	Paclitaxel
14	928672-86-0	Canagliflozin HemiHydrate	37	137281-23-3	Pemetrexed Disodium
15	41575-94-4	Carboplatin	38	53123-88-9	Rapamycin
16	50935-04-1	Carubicin	50	135062-02-1	Repaglinide
17	288383-20-0	Cediranib	39	945667-22-1	Saxagliptin Hydrate
18	15663-27-1	Cisplatin	40	709031-78-7	Saxagliptin Hydrochloride
19	877399-52-5	Crizotinib	41	486460-32-6	Sitagliptin
20	171500-79-1	Dalbavancin	42	654671-77-9	Sitagliptin Phosphate Hydrate
21	114977-28-5	Docetaxel	44	85622-93-1	Temozolomide
22	148408-66-6	Docetaxel TriHydrate	45	477600-75-2	Tofacitinib
23	25316-40-9	Doxorubicin hydrochloride	46	540737-29-9	Tofacitinib Citrate
24	133040-01-4	Eprosartan	47	170791-09-0	Trityl Candesartan Cilexetil

ABOUT DELIVERY:

#1 Products can be sent out within 24 hours after payment.

#2 Secure and discreet shipment.

#3 Various methods for your choice, like DHL/FedEx/SF-express.

OUR COMMITMENT:

#1 We are manufacturer with own factory and we sale this product at a best quality and low price.#2 All product listed is available in stock, please contact the sale for more details.#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.

CONTACT US:

Telephone	+86-027-87002705
Mobile	+86-13277093700
Skype	newbiopharmtech
FaceBook Page	https://www.facebook.com/newbiopharma/
Facebook Group	https://www.facebook.com/groups/1739616069613416/
Website	http://www.newbiopharm.com/
Online Store	http://biocar.en.made-in-china.com/

If you want to source ... #1 Pharmaceutical raw material, #2 Oncology drug APIs, #3 Antibiotics or fine chemicals, We are a reliable manufacturer and supplier in China.NEWBIO would like to ... #1 We foucus on the high purity and high quality; #2 We provide the raw materials at a good price; #3 We have the best service and we are always there for you.Please contact us for more infomation!!!