Corticotropin

Detailed Product Description  99% Injectable Polypeptide Hormones Corticotropin CAS 9002-60-2 ACTH For Muscle Building & Collagen Diseases  Quick Details: •    Corticotropin•    Alias : Adrendcorticotrophic hormone, ACTH, ACTH 1-39 , acethropan•    CAS NO. : 9002-60-2•    EINECS 232-659-7•    MF : C207H308N56O58S•    MW : 4541.07•    MS : •    Purity (HPLC): 99%•    Appearance: White or light yellow powder, odorless, moisture, soluble in water, soluble in 70% acetone and 70% ethanol•    Grade : Pharmaceutical Grade•    Storage: Closed, −20°C preservation•    Manufacturer : Hezhong•    Usage : Hormone kind medicine, promote the secretion of adrenal cortical hormone, used in active rheumatism, rheumatoid arthritis, lupus and other collagen diseases. Clinical use of cortisone similar. Description: This product is composed of 39 amino acid residues, species differences only in the 25-33 position, 1-24 bits of the fragment with all the activity, twenty-fourth amino acid after the part only to maintain stability of the whole polypeptide structure. In the solution is highly - Helical structure. By partial hydrolysis of pepsin is still active.This product is poor efficacy of oral invalid; intramuscular injection; intravenous injection effect is fast, but has a half-life of only 15min, hold time 1-3h.Adrenocorticotropic hormone, commonly referred to as ACTH and also known as corticotropin, is a polypeptide hormone produced in and secreted by the anterior pituitary gland. It is a key component in the hypothalamic-pituitary-adrenal axis, often produced in response to exogenous biological stress along with corticotropin-releasing hormone (which is also from the hypothalamus.) Its effects include increased production and release of corticosteroids and, as its name suggests, cortisol from the adrenal cortex.ACTH acts through the stimulation of cell surface ACTH receptors, which are located primarily on adrenocortical cells of the adrenal cortex. This results in the synthesis and secretion of gluco- and mineralo-corticosteroids and androgenic steroids. The ACTH receptor is a seven-membrane-spanning G protein-coupled receptor. Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A. This ultimately results in stimulation of steroidogenesis. Steroidogenesis. Steroidogenesis is the biological process by which steroids are generated from cholesterol and transformed into other steroids. The pathways of steroidogenesis differ between different species, but the pathways of human steroidogenesis are shown in the figure. Products of steroidogenesis include: androgens testosterone estrogens and progesterone corticoids cortisol aldosterone ACTH acts at several key steps to influence the steroidogenic pathway in the adrenal cortex: ACTH stimulates lipoprotein uptake into cortical cells. This increases the bio-availability of cholesterol in the cells of the adrenal cortex. ACTH increases the transport of cholesterol into the mitochondria and activates its hydrolysis. ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. This results in the production of pregnenolone. Application: Hormone drugs. For epinephrine cortical function diagnosis, prevent atrophy of cortex long-term use of corticosteroids after stopping drug, can also be used for the treatment of some collagen diseases, severe bronchial asthma, epilepsy, myasthenia gravis. Specifications : Product name    CorticotropinAppearance    White or light yellow powderAssay    99%Molecular formula    C207H308N56O58SMolecular weight    4541.07Package    1g/bag, 10g/bag, 50g/bag or as your requestShipping    Fast and secure shipping by DHL,EMS,UPS,TNT, FedEx..Shipping leading time    Within 12 hours after receiving the paymentPayment Terms    Western Union, Money Gram , T/T, PayPalPrice    Negotiable