Lapatinib is an oral, small-molecule, reversible tyrosine kinase inhibitor that dually targets the epidermal growth factor receptor (EGFR/HER1) and human epidermal growth factor receptor 2 (HER2/ERBB2…
Vismodegib is an oral, first-in-class, small-molecule inhibitor of the Hedgehog signaling pathway, used for the treatment of locally advanced or metastatic basal cell carcinoma.
Vandetanib is an oral, once-daily, small-molecule inhibitor of multiple tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR), epidermal growth factor receptor (EGFR), and re…
Erlotinib hydrochloride is the hydrochloride salt of erlotinib, an oral, first-generation, reversible tyrosine kinase inhibitor that selectively targets the epidermal growth factor receptor (EGFR), us…
Tucatinib is an oral, highly selective, small-molecule inhibitor of the HER2 tyrosine kinase, used in combination with trastuzumab and capecitabine for the treatment of advanced HER2-positive breast c…
Selitrectinib is an investigational, oral, next-generation, highly selective TRK kinase inhibitor, specifically designed to overcome acquired resistance to prior TRK inhibitor therapy, particularly th…
Larotrectinib sulfate is the sulfate salt of larotrectinib, a first-in-class, highly selective, and potent oral inhibitor of the tropomyosin receptor kinase (TRK) family, used to treat solid tumors ha…
Repotrectinib is an oral, next-generation, macrocyclic tyrosine kinase inhibitor designed to potently inhibit ROS1 and TRK kinases, particularly effective against solvent-front mutations that cause re…
Ensartinib is an oral, potent, and highly selective second-generation inhibitor of anaplastic lymphoma kinase (ALK), developed to overcome resistance and improve efficacy against central nervous syste…
Cabozantinib S-malate is the S-malate salt of the oral, multi-targeted tyrosine kinase inhibitor cabozantinib, primarily used in the treatment of advanced renal cell carcinoma, hepatocellular carcinom…
Crizotinib is an oral, first-in-class, small-molecule inhibitor of anaplastic lymphoma kinase (ALK), ROS1, and MET tyrosine kinases, primarily used to treat ALK-positive or ROS1-positive non-small cel…
Capmatinib is an oral, selective, and potent small-molecule inhibitor of the mesenchymal-epithelial transition (MET) tyrosine kinase, used in the treatment of metastatic non-small cell lung cancer har…
Niraparib tosylate is the tosylate salt form of the poly (ADP-ribose) polymerase (PARP) inhibitor niraparib, used in the maintenance treatment of certain platinum-sensitive, recurrent cancers.
Sorafenib is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI) and the first systemic agent shown to improve survival in advanced hepatocellular carcinoma (HCC).
Lenalidomide is an oral immunomodulatory drug (IMiD) derived from thalidomide, used in the treatment of multiple myeloma, myelodysplastic syndromes, and certain lymphomas.
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