brepocitinib

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Selling leads
brepocitinib
Posting date : Jun 23, 2026
Membership
Free Member Scince Jun 22, 2026
FOB Price
1
Min. Order Quantity
10g
Supply Abillity
50000kgs
Port
Beijing
Payment Terms
100% TT in Advance
Package
1
Keyword :
API
Category
Contact
Winnie Wang
Selling Leads Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
JINLAN Brand
Model Number
1883299-62-4
HS-CODE
-
Package & Delivery Lead Time
Package
1
Delivery Lead Time
7-14
Detailed Description
PF06700841, also known as Brepocitinib or PF-841, is a small-molecule kinase inhibitor with CAS No. 1883299-62-4, molecular formula C₁₈H₂₁F₂N₇O and molecular weight of 389.4. It exhibits potent inhibitory activity against Tyk2, JAK1 and JAK2 kinases, with IC50 values of 23 nM, 17 nM and 77 nM respectively, widely utilized for preclinical research of inflammatory and autoimmune disorders related to JAK/Tyk2 signaling pathways.
This compound appears as white to off-white powder, insoluble in water yet soluble up to 78 mg/mL (200.31 mM) in both DMSO and ethanol. Its predicted physicochemical parameters include a boiling point of 637.1±65.0 °C, density of 1.63±0.1 g/cm³ and pKa of 7.28±0.10. Unlike most similar kinase inhibitors, it can be stably stored at room temperature without cryogenic conditions. Supplied as high-purity research-grade reagent, it serves as a critical tool compound for kinase screening, cellular functional assays and early-stage drug discovery targeting JAK family kinases.

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