Pharmaceutical Grade API Sorafenib Tosylate CAS 475207-59-1

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Pharmaceutical Grade API Sorafenib Tosylate CAS 475207-59-1
Posting date : May 18, 2023
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Free Member Scince May 09, 2023
FOB Price
$1000/kg
Min. Order Quantity
1kg
Supply Abillity
500kg
Port
Qingdao
Payment Terms
TT,LC
Package
5kg/drum
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Melissa wang
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Product Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
Loncom
HS-CODE
2920-90
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Package
5kg/drum
Detailed Description

Sorafenib tosylate 475207-59-1

Product Name: Sorafenib tosylate

CAS: 475207-59-1

MF: C28H24ClF3N4O6S

MW: 637.0265696

EINECS: 641-758-8General

Description:   

Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and colon cancer.The agent is classified as a multikinase inhibitor because ofits action on numerous kinase enzymes including thePDGF-R, Kit, and Raf. Sorafenib is 39% to 48% bioavailable and CYP3A4-mediated metabolism giveseight identified metabolites including the N-oxide, which isequally active with the parent. However, the majority of thedrug in plasma is present as the parent compound.Sorafenib is highly protein bound (99.5%). The drug iseliminated primarily in the feces (77%) with 19% appearingin the urine as glucuronides (UGT1A1) and has a eliminationhalf-life of 24 to 48 hours. The most commonly seentoxicity is skin rash that normally occurs within the first6 weeks of therapy. Other adverse effects include hypertension,fatigue, increased wound healing time, and increasedrisk of bleeding.

Uses: An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.


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