- Methylcinnamic acid
|
CAS
|
1866-39-3
|
|
EinecsNo
|
217-479-9
|
|
Molecular Formula
|
C10H10O2
|
|
Molecular weight
|
162.19
|
|
Purity
|
99%
|
|
LogP
|
2.09280
|
|
PSA
|
37.30000
|
|
Quality standard
|
Enterprise standard
|
|
Melting point
|
196-198 degree C
|
|
Boiling point
|
300.6 degree C at 760 mmhg
|
|
Flash point
|
206.1 degree C
|
|
Density
|
1.147 g/cm3
|
|
Vapor pressure
|
0.000494mmhg at 25 degree C
|
|
Physical property
|
Insoluble in water, Soluble in organic solvent like ethanol or ethyl acetate
|
|
Appearance
|
White crystal
|
|
Stability
|
Stable under normal temperatures and pressures
|
|
Storage
|
Store in a cool, dry place. Store in a tightly closed container
|
|
Synonyms
|
4-Methylciamicacid;P-methycinnamic acid;BASF Luwipal 044;3-(4-methylphenyl)-2-propenoic acid;3-(p-Tolyl)acrylic acid;trans-4-methylcinnamic acid;P-METHYLCINNAMIC ACID;2-Propenoic acid, 3-(4-methylphenyl)-;3-P-TOLYL-ACRYLIC ACID;RARECHEM BK HC T309;(2E)-3-(4-methylphenyl)prop-2-enoic acid;4-MethylcinnaMic Acid
|
Solvent:
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Description:
5-Methoxycinnamic acid is a photosensitive compound, also known as para-methoxycinnamate or O-methyl-p-coumarate, belongs to the class of organic compounds known as cinnamic acids. These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. 4-Methoxycinnamic acid exists as a solid and is considered to be practically insoluble (in water) and relatively neutral. 4-Methoxycinnamic acid has been detected in multiple biofluids, such as urine and blood. Within the cell, 4-methoxycinnamic acid is primarily located in the membrane (predicted from logP). Outside of the human body, 4-methoxycinnamic acid can be found in turmeric and wild celery. This makes 4-methoxycinnamic acid a potential biomarker for the consumption of these food products.
Main Applications:
1. methyl cinnamic acid is mainly used as an important intermediate in organic synthesis.
2. p-MCA exerted antihyperglycemic/hypoglycemic effect by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
- methyl cinnamic acid shows various pharmacologic actions such as hepatoprotective and antihyperglycemic activities, it also can stimulate insulin secretion from pancreatic β-cells by increasing Ca2+ influx via the L-type Ca2+ channels, but not through the closure of ATP-sensitive K+ channels.
- 4-Methoxycinnamic acid can strongly inhibit the diphenolase activity of mushroom tyrosinase, with the IC 50 value of 0.42 mM, and the inhibition is reversible.
5. Inhibitory effects of cinnamic acid and its derivatives on the diphenolase activity of mushroom ( Agaricus bisporus ) tyrosinase.
6. Natural products modulate Shigella-host-cell interaction.
7. Photosensitive semiconductor nanocrystals, photosensitive composition comprising semiconductor nanocrystals and method for forming semiconductor nanocrystal pattern using the same
8. Mechanisms of p-methoxycinnamic acid-induced increase in insulin secretion.
9. Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes.
0 likes
China [CN] 
Click enlarge Image