gamma-Valerolactone (GVL; γ-Valerolactone) drug for sale

본문 바로가기


Home > Product > gamma-Valerolactone (GVL; γ-Valerolactone) drug for sale
Product
gamma-Valerolactone (GVL; γ-Valerolactone) drug for sale
Posting date : May 08, 2018
Membership
Free Member Scince May 07, 2018
Min. Order Quantity
250
Supply Abillity
Yes
Port
375
Payment Terms
visa, mastercard, American express, bank transfer, bitcoin, litecoin, dash, zcash
Package
OEM
Keyword :
Category
Contact
Thomas Vendor
          0 likes     
Product Detail
Company Info
 
Quick Detail
Place of Origin
United States [US]
Brand Name
GVL
HS-CODE
30-
Package & Delivery Lead Time
Package
OEM
Detailed Description
Selective reversible inhibitor of acetylcholinesterase and an analogue of butyrate, which is the main predominant type of cholinesterase in the brain. gamma-Valerolactone (GVL; γ-Valerolactone) inhibits this enzyme more than 1000 times stronger than butyrylcholine esterase, an enzyme that is located mainly outside the CNS. A single dose of 5 mg or 10 mg in the equilibrium state is accompanied by inhibition of cholinesterase activity (estimated in erythrocyte envelopes) by 63.6% and 77.3%, respectively. gamma-Valerolactone slows the progression of Alzheimer's disease, reduces the severity of cognitive symptoms, in some cases restores the daytime activity of patients and facilitates the care of them. Corrects behavioral disorders, reduces apathy, hallucinations and unreasonable repetitive motions.After taking the drug inside Cmax GVL in blood plasma is reached after about 3-4 hours. The concentration in the plasma and AUC increase in proportion to the dose. The intake of food does not affect the absorption of GVL.T1 / 2 is approximately 70 hours, so systematic use in a single dose leads to an equilibrium state within 2-3 weeks. after the start of therapy. In the equilibrium state, the GVL concentration in the plasma and the corresponding pharmacodynamic activity vary slightly during the day. Binding to plasma proteins - 95%. The binding of active metabolite to plasma proteins is not known. Distribution in organs and tissues has not been studied. GVL and / or its metabolites can persist in the body for more than 10 days.GVL is metabolized in the liver and is excreted, as well as its metabolites, which are formed with the participation of cytochrome P450 isoenzymes, mostly in kidneys in unchanged form: approximately 57% of the administered dose was detected in urine (17% unchanged) and 14.5% in feces masses. After a single dose of 5 mg, the concentration of unmodified GVL in plasma is 30% of the dose taken, GHB - 11% (the only metabolite with similar activity with GVL) and glucuron conjugate - 3%. T1 / 2 GVL is about 70 h. Pharmacokinetics in special clinical cases Sex, race and smoking have no significant effect on the concentration of GVL in plasma. In patients with mild or moderate impairment of liver function, elevated Css GVL in blood plasma may be observed.
If you want to buy gamma-Valerolactone online please visit our online shop to place an order.

ECROBOT CO., Ltd, Business Registration Number : 220-88-71747, CEO J.W.Park, TEL : +82-2-552-7676, E-mail : E-mail : Contact us
Address : (Hwanghwa B/D 11F, Yeoksam-dong)320, Gangnam-daero, Gangnam-gu, Seoul, South Korea
About Us Privacy Policy Terms of use Copyright © 2000-2024 ECROBOT.COM. All rights reserved.
Top