Diclofensine (Ro 8-4650) drug for sale

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Home > Product > Diclofensine (Ro 8-4650) drug for sale
Product
Diclofensine (Ro 8-4650) drug for sale
Posting date : May 08, 2018
Membership
Free Member Scince May 07, 2018
Min. Order Quantity
10
Supply Abillity
Yes
Port
150
Payment Terms
visa, mastercard, American express, bank transfer, bitcoin, litecoin, dash, zcash
Package
OEM
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Category
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Thomas Vendor
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Product Detail
Company Info
 
Quick Detail
Place of Origin
United States [US]
Brand Name
Diclofensine
HS-CODE
30-
Package & Delivery Lead Time
Package
OEM
Detailed Description
Diclofensine (Ro 8-4650) is a selective serotonin reuptake inhibitor (5-hydroxytryptamine, 5-HT) by neurons of the brain, which determines its antidepressant effect and effectiveness in the treatment of obsessive-compulsive (OCD) and panic disorder. Diclofensine has a low affinity for m-cholinergic receptors (has a weak anticholinergic effect), alpha1, alpha2 and beta adrenoreceptors, as well as dopamine (D2), 5HT1-like, 5HT2-like and histamine H1 receptors. Diclofensine does not impair psychomotor functions and does not potentiate the inhibitory effect of ethanol on them. According to the study of behavior and EEG in diclofensine, weak activating properties are revealed when it is administered at doses higher than those required to inhibit the capture of serotonin. In healthy volunteers, it does not cause a significant change in blood pressure, heart rate and EEG. After ingestion diclofensine is well absorbed from the digestive tract. Simultaneous food intake does not affect the absorption and pharmacokinetics of diclofensine. The equilibrium state is reached after 7-14 days after the start of therapy, further pharmacokinetics with prolonged therapy does not change. The clinical effects of diclofensine (side effect and efficacy) do not correlate with its concentration in the plasma. Since diclofensine is subjected to the effect of "first passage" through the liver, its amount determined in the systemic circulation is less than that absorbed from the gastrointestinal tract. With increasing dose of diclofensine or with multiple dosing, a partial absorption of the effect of "first passage" through the liver and a decrease in plasma clearance of diclofensine occur. As a result, an increase in the plasma diclofensine concentration and fluctuations in the pharmacokinetic parameters is possible, which can be observed only in those patients who, when taking the drug at low doses, achieve low levels of diclofensine in the plasma. Diclofensine is extensively distributed in tissues, and pharmacokinetic calculations show that only 1% of it is present in the plasma, and at therapeutic concentrations 95% is associated with plasma proteins.
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