u48800

The introduction of the U48800:

  U-48800 is an opioid analgesic drug developed by a team at Upjohn in the 1970s that acts as a selectiveagonist of the µ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor and has around 7.5 x the potency of morphine in animal models.

  U-48800 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the keymoieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.

  U-48800 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures.Although not used medically, the selective kappa ligands are used in research

• name: u-48800 

• purity: 99.9% 

• colour: many colour 

• appearance: powder and crystal 

• chemical: Pharmaceutical Intermediates 

• delievery time: 2-3working days 

• payment way: TT moneygram western union paypal bitcoin 

• shipping way: ems,dhl,fedex,eub 

• Model No.: researchh chemical 

• Place of Origin: Shanghai  

• Min.Order: 10 Gram

• Means of Transport: Ocean, Air