Toremifene Citrate is a Selective Estrogen Receptor Modulator derived from triphenylethelyne, it is used to treat breast cancer in post-menopausal women and Licensed in the United States under the brand name Fareston, It does this by exerting estrogen antagonistic effects in certain tissue, this is actually the same mechanism of action found in Nolvadex.Toremifene citrate is an oral selective estrogen receptor modulator, which helps oppose the actions of estrogen in the body ;it has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body ;At the hypothalamus and pituitary ; estrogen acts in cooperation with the male body, negative feedback loop to send a signal to decrease the secretion of LH, and when LH secretion is lowered; so are natural testosterone levels;Fareston may act as an estrogen antagonist in the hypothalamus and pituitary; in order to increase testosterone production.
Basic Application:Toremifene Citrate improved lipid profiles; particularly as an enhancer of high density lipoprotein cholesterol; it improved low density lipoprotein cholesterol levels;Both fareston and tamoxifen selective estrogen receptor modulators and equivalent treatments for metastatic breast cancer ;No significant differences were found between treatment with either tamoxifen or fareston Treatment of HR-positive patients with either tamoxifen or toremifene is appropriate ;In treating idiopathic oligozoospermia ; tamoxifen and fareston are roughly equally effective but raloxifene is not ;The antiestrogenic effects of SERMs at the hypothalamic level result in a statistically significant increase of gonadotropin levels; which is more marked for tamoxifen and fareston compared with raloxifene
Dosage:For bodybuilding purposes, a dose of 40-60 mg/day seems to be a good starting point. If the user is trying to fight existing gynecomastia, they may choose to double the dose and add an aromatase inhibitor like Aromasin with it. For PCT, some users will kick-start with 100-120 mg/day and then lower to 40-60 mg/day for 4-6 weeks.
Function:Toremifene citrate is an oral selective estrogen receptor modulator (SERM, which helps oppose the actions of estrogen in the body; Licensed in the United States under the brand name Fareston; toremifene citrate is FDA-approved for use in advanced ;metastatic, breast cancer; It is also being evaluated for prevention of prostate cancer under the brand name Acapodene;It has already been covered that Toremifene is a SERM; and serves to block Estrogen at various receptor sites in certain tissues within the body ;breast tissue in particular .As a layman explanation; Toremifene pretends to be a fake. Estrogen that occupies Estrogen receptors within breast tissue; With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there; Toremifene does not reduce total blood plasma levels of Estrogen; In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland ;this essentially ;tricks; the hypothalamus into thinking there is little or no circulating Estrogen levels in the body; causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels;Toremifene is also agonistic to Estrogen receptors in other tissues in the body ;within the liver in particular;; This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus; it will act as an Estrogen within the liver; This can have beneficial impacts especially during an anabolic steroid cycle; such as improving and shifting cholesterol levels into a more favorable range.
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