Beloranib CAS 251111-30-5,529511-79-3 | Global Trade leader ecrobot

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Beloranib CAS 251111-30-5,529511-79-3

Posting date : Aug 26, 2016

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Free Member Scince Aug 26, 2016

FOB Price

Min. Order Quantity

Supply Abillity

1000kg

Port

Hong Kong

Payment Terms

Paypal,Bitcoin,WesternUnion,Webmoney,Escrew

Package

custom

Keyword :

Beloranib

Category

CHEMICAL | Inorganic chemic | Carbon (carbon b | Carbon (carbon b

Contact

Peter Wong

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Company Info

Quick Detail

Place of Origin

China [CN]

Brand Name

roughchem

Model Number

HS-CODE

2803-00

Package & Delivery Lead Time

Package

custom

Detailed Description

Beloranib CAS 251111-30-5,529511-79-3

Beloranib is a former drug candidate for the treatment of obesity. It was discovered by CKD Pharmaceuticals and its clinical development was led by Zafgen.Drug development for the product was halted in 2016.

Beloranib, an analog of the natural chemical compound fumagillin, is an inhibitor of the enzyme METAP2. It was originally designed as angiogenesis inhibitor for the treatment of cancer.However, once the potential anti-obesity effects of METAP2 inhibition became apparent, the clinical development began to focus on these effects and beloranib has shown positive results in preliminary clinical trials for this indication.

A Phase I trial was published in 2013,finding a dose that led to weight loss in obese women in comparison to placebo. Results from a Phase II clinical trial for obesity were promising with clinically meaningful weight loss and improvements in cardiometabolic risk factors in the treated group. Zafgen continued with a Phase III trial for Prader–Willi syndrome.

In December 2015, Zafgen halted the Phase III clinical trial of beloranib for Prader–Willi syndrome after a second patient death in order to determine whether the deaths were treatment-related.After discussions with the Food and Drug Administration indicated that the obstacles to gaining approval were insurmountable, product development for beloranib was ended.