Anti Inflammatory Local Anesthesia Phenacetin CAS 62-44-2 Pain-Relieving Drug

 

1.  Quick Detail:English name: PhenacetiEnglish Synonyms: 1-acetamido-4-ethoxybenzene; para-Acetophenetidide; p-acetophenetidine; p-acetophenetide; p-acetphenetidin; paracetophentidin; p-Ethoxyacetanilide; 4'-ethoxyacetanilide; Para-phenaceti; acet-p-phenalide; acet- p-phenetidin; aceto-para-phenalide; aceto-para-phenetidide; Acetophenetidine; acetophenetin; acetylphenetidin; coricidin; empirin compound;N- (4-ethoxyphenyl) -acetamide; N-Acetyl-4-ethoxyaniline; N-acetyl-p -phenetidine; phenacet; phenacitin; phenazetin; Phorazetim; pyraphenCAS: 62-44-2EINECS Number: 200-533-0Formula: C10H13NO2MW: 179.2157Density: 1.099g / cm3Melting point: 133-138 ºCBoiling point: 355.1 ° C at 760 mmHgFlash Point: 168.5 ° CWater-soluble: 0.076 g / 100 mLVapor Pressure: 3.21E-05mmHg at 25 ° CUses:Anti-inflammatory drugsAssay:99%Appearance: White or almost white crystalline powder 2.  Descriptions:Phenaceti is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenaceti. 3.  Applications:Phenaceti was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenaceti-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenaceti in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result some branded, previously phenaceti-based preparations continued to be sold, but with the phenaceti replaced by safer alternatives. A popular brand of phenaceti was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenaceti. Paracetamol is a metabolite of phenacetiwith similar analgesic and antipyretic effects, but the new formulation has not been found to have phenaceti's carcinogenicity. Phenaceti is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs. Due to low cost phenaceti is used for research into the physical and refractive properties of crystals.It is an ideal compound for this type of research