GHRP-6 (Growth hormone releasing peptide)

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GHRP-6 (Growth hormone releasing peptide)
Posting date : Dec 16, 2015
Membership
Free Member Scince Dec 16, 2015
FOB Price
1
Min. Order Quantity
1g
Supply Abillity
100kg/month
Port
Shengzhen,HK
Payment Terms
T/T,Western Union,Money Gram,Bitcoin
Package
discreet packing
Keyword :
Category
Contact
Noul
Selling Leads Detail
Company Info
 
Quick Detail
Place of Origin
China [CN]
Brand Name
YC
Model Number
87616-84-0
HS-CODE
2937-19
Package & Delivery Lead Time
Package
discreet packing
Delivery Lead Time
1-2 days after receive your payment
Detailed Description
GHRP-6 (Growth hormone releasing peptide)
· Alias: GROWTH HORMONE RELEASING PEPTIDE-6; [HIS1, LYS6]-GHRP; HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2; H-HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2
· CAS: 87616-84-0
· M.F.: C46H56N12O6
· M.W.: 873.01
· Purity (HPLC): 98.0%min.
· Appearance: White powder
· Single Impurity (HPLC): 1.0%max
· Amino Acid Composition: ±10% of theoretical
· Peptide Content (N%): >80.0%
· Water Content(Karl Fischer): <6.0%
· Acetate Content (HPIC): <12.0%
· MS(ESI): Consistent
· Mass Balance: 95.0~105.0%
· Grade : Pharmaceutical Grade
· Storage: Closed, below 2 ~ 8°C preservation
· Manufacturer :
· Usage : GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is composed of both natural and isomeric forms of those 6 amino acids.This sequence provides a signal to the body to begin secreting Growth Hormone release while also blocking Somatostatin, a hormone that inhibits the release of Growth Hormone.
Description:
GHRP-6 is a potent stimulator of natural Growth Hormone release. GHRP-6 is a Hexa-peptide that promotes food intake by stimulating hunger and helps increase energy metabolism. Growth Hormone Releasing Peptides, similar to GHRP-6, are most commonly used for treatment of Growth Hormone (GH) deficiencies, eating disorders, obesity, etc. Research has shown that use of these HGH Peptides increases lean muscle mass, strength, stamina and decreases body fat.
Application:
GHRPs are not simply surrogates of GHRH, instead GHRP-6 is an artificial activator of a separate newly discovered receptor called Growth Hormone Secretagogue Receptor (GHS-R). Soon Ghrelin was discovered, the endogenous ligand that binds to the GHS-R. Both Ghrelin and all the synthetic compounds such as GHRP-6 were termed "Growth Hormone Secretagogues" (GHSs). One side effect of GHRP-6 is a significant increase in appetite due to stimulating the release of Ghrelin, a peptide that is released naturally in the lining of the stomach that increases hunger and gastric emptying. Also, GHRP-6 causes stimulation of the anterior pituitary gland which causes an increase in Growth Hormone release. The increased amounts of Growth Hormone can cause the liver to secrete the hormone IGF-1, which improves the animal body’s ability to burn fat and build muscle. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of Growth Hormone release, GHRP-6 can re-stimulate the production of Growth Hormone.
Specifications :
Product Name
GHRP-6
Column
Sinochrom ODS-BP, 4.6*250mm, 5um
Solvent A
0.1%Trifluoroacetic in 100% Acetonitrile
Solvent B
0.1%Trifluoroacetic in 100% Water
Gradient
 
A
B
0.0min
20%
80%
25.0min
45%
55%
25.1min
100%
0%
30.0min
Stop
Flow rate
1.0ml/min
Wavelength
220nm
Volume
20ul
 
GHRP-6 is an injectable peptide in the category of growth hormone releasing peptides, or GHRP’s. The most common use of these peptides is to increase GH production. Other peptides in this category include GHRP-2, hexarelin, and ipamorelin. With regard to increasing GH, all of these work similarly, and there is no need or advantage to combining them. Instead, the one most suited for the particular case is chosen.
The principal use of GHRP-6 is to provide increased GH levels, which also results in increased IGF-1 levels. This aids fat loss and in some instances aids muscle gain as well. Generally, GHRP use is chosen as an alternate to GH use, and only rarely is combined with GH.
Reasons to prefer GHRP-6 over other GHRP’s are its effect on increasing appetite (which also can be a disadvantage), and its demonstrated value in reducing inflammation and helping to heal injury, particularly tendinitis.
When to use GHRP-6
GHRP-6 is most generally used for the same purposes that GH might be used, but may be chosen where a cost advantage exists favoring GHRP-6, GH is not available, or the individual prefers the idea of stimulating his own GH production to injecting GH.
These purposes can include increased fat loss, improved muscle gain when used in combination with anabolic steroids, cosmetic improvement of the skin, and improved healing from injury.
There is no need to cycle GHRP use, and so therefore GHRP-6 may be used whenever it is thought to be useful for any of the above reasons. However, when usage is ongoing instead of short-term amplification of a steroid cycle or fat-loss program, I recommend limiting dosage to the minimum end of the suggested dosage range.
Increased effect from combining GHRP-6 with a GHRH
While GHRP-6 is capable of inducing large increases in GH production when used alone, a given dose will show markedly more effect what a GHRH (growth hormone releasing hormone) peptide is taken at the same time. Alternately, when combining a GHRH with GHRP-6, only about half or a third as much GHRP-6 is needed to obtain the same increase in GH production.
For this reason, it’s a common choice to combine a GHRH with a GHRP, but excellent results are often obtained without doing so. A preferred choice of GHRH is Mod GRF 1-29(also known as CJC-1295 without DAC.)
How to use GHRP-6
GHRP-6 is most commonly provided in small vials of 5 mg, which should be stored under refrigeration. (It is acceptable however for them to be mailed unrefrigerated.) The vial is diluted with a convenient volume of sterile or bacteriostatic water. For example, the vial might be diluted with 2.5 mL of water, yielding a solution of 2 mg/mL (2000 mcg/mL.) After the water addition, the vial again will be stored under refrigeration.
When dosing, an appropriate volume will be drawn from the vial with (typically) an insulinsyringe, according to the desired dose and the concentration of the preparation. In the above example, a 100 mcg dose would require only 0.05 mL, or “5 IU” as marked on an insulin syringe. A 300 mcg would require 0.15 mL, or “15 IU” as marked on an insulin syringe.
Injection may be subcutaneous, intramuscular, or intravenous according to personal preference.
Dosing will ordinarily be at least twice per day and preferably 3x/day for best effect, taken at least 30-60 minutes before a meal and at a time of non-elevated blood sugar (in other words, after blood sugar has had time to fall since the most recent meal.) The amount taken generally will be from 50-300 mcg at a time. When using a GHRH along with GHRP-6, dosing should be reduced to 50-100 mcg at a time.
For increase in GH levels, higher doses within the suggested range definitely increase effect. With regard to healing benefit, for example for tendonitis, the low end of the range is often entirely sufficient and noticeably greater effect is not necessarily seen with increased dose.
While there is no sharp cut-off between a solution of GHRP-6 still being good and having lost potency with time, as a general guideline, a vial should be used within a month of having been reconstituted. Past this, I would discard the vial and start a new one.
Pharmacological class: Mimetic of ghrelin
GHRP-6 and all GHRP’s are mimetics of ghrelin, a hormone produced by cells of the stomach in response to a fasted condition, including brief fasts. Ghrelin and ghrelin mimetics work by activating the ghrelin receptor, also called the growth hormone secretagogue receptor (GHS-R1a). Elevated ghrelin levels act towards increasing GH levels by stimulation of ghrelin receptors in the pituitary.
Injection of GHRP-6 or any GHRP stimulates GH release in essentially the same way as fasting-induced elevation of ghrelin levels. The effect can be markedly greater, however. Supraphysiological levels of GH are easily achieved with proper dosing of any GHRP.
Other activities of ghrelin, and potentially of GHRP-6
Ghrelin has many activities in the body besides stimulating GH release. It stimulates appetite, is cardioprotective, can help protect cells against oxidative damage, can reduce inflammation and promote healing, and can promote fat-burning in muscle. There is also some effect on increase in cortisol production via increase in ACTH, and increase in prolactin. However, where the activity of ghrelin is comparable to that which ordinarily occurs during fasting, effects on cortisol and prolactin likewise are comparably only to that experienced while fasting.
Ghrelin itself so far as I know has not been used as a performance-enhancing drug. In contrast, experience with GHRP’s is quite extensive. GHRP-6 in particular has in many cases been effective in treating tendonitis, which may well be due to its activity at the ghrelin receptor.
Broadly speaking, it’s long been a widespread view that fasting can in many instances provide healthful effects beyond simple fat loss. It’s speculative to say that increased ghrelin levels must be a major cause of such effect (if granting the effect), but it’s entirely consistent with the scientific literature that such elevation of ghrelin levels may have health benefits. Appropriate-dosed and cycled GHRP use may at least partially provide such benefits, particularly with regard to anti-inflammatory and healing effect.
There are indications in the literature of ghrelin acting to promote fat-storage, but this appears to be tissue-specific, for example in the liver. In bodybuilding, by no means has any such effect been apparent with GHRP-6. Instead, GHRP-6 has been effective as a cutting drug, provided that food intake is controlled.
Because some GHRP’s are equally effective as others in increasing GH but differ in effect on hunger or ACTH stimulation, it seems likely that there may be differences in ghrelin receptors between different tissues, or differences in function (for example with cofactors.) This is the most likely explanation for GHRP-6 being effective in stimulating hunger and helping heal tendinitis, while GHRP-2 stimulates hunger less and may have less value for healing.

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